FCRLA - Fc receptor like A Gene
Also Known as FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2
Species: Homo sapiens
About FCRLA
This gene has 16 transcripts (splice variants), 209 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues.
Summary
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
FCRLA Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001184866.2 | NP_001171795.2 | Fc receptor-like A isoform 1 precursor |
| NM_001184867.2 | NP_001171796.2 | Fc receptor-like A isoform 3 precursor |
| NM_001184870.2 | NP_001171799.2 | Fc receptor-like A isoform 4 precursor |
| NM_001184871.2 | NP_001171800.2 | Fc receptor-like A isoform 7 precursor |
| NM_001184872.2 | NP_001171801.2 | Fc receptor-like A isoform 5 |
| NM_001184873.2 | NP_001171802.2 | Fc receptor-like A isoform 6 precursor |
| NM_001366195.2 | NP_001353124.2 | Fc receptor-like A isoform 8 precursor |
| NM_001366196.2 | NP_001353125.2 | Fc receptor-like A isoform 9 precursor |
| NM_032738.4 | NP_116127.4 | Fc receptor-like A isoform 2 precursor |
FCRLA Protein Structure
Ig_2: Immunoglobulin domain (103 - 174)
Ig_2: Immunoglobulin domain (194 - 283)
- 0
- 100
- 200
- 300
- 382 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
Fc receptor-like A |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Melanoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | FCRLA | RGD | RGD:1306176 |
| Felis catus | FCRLA | VGNC | VGNC:62217 |
| Mus musculus | FCRLA | MGD | MGI:2138647 |
| Canis familiaris | FCRLA | VGNC | VGNC:40810 |
| Bos taurus | FCRLA | VGNC | VGNC:28939 |
| Macaca mulatta | FCRLA | VGNC | VGNC:72526 |
| Others | FCRLA | NCBI |