ARHGAP19 - Rho GTPase activating protein 19 Gene

Homo sapiens

Gene ID: 84986 | Gene type: protein coding

About ARHGAP19

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,222,179-97,292,637 (from NCBI)

This gene has 7 transcripts (splice variants), 251 orthologues and 3 paralogues. Broad expression in testis (RPKM 13.6), bone marrow (RPKM 8.1) and 24 other tissues.

Summary

Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

ARHGAP19 Products(3)

mRNA	Protein	Name
NM_001204300.2	NP_001191229.1	rho GTPase-activating protein 19 isoform 2
NM_001256423.2	NP_001243352.1	rho GTPase-activating protein 19 isoform 3
NM_032900.6	NP_116289.4	rho GTPase-activating protein 19 isoform 1

ARHGAP19 Protein Structure

RhoGAP

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 19

putative RhoGAP protein

Related Diseases

Diseases

Alias

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Malignant Otitis Externa

Necrotising Otitis Externa

Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00919	ARHGAP19 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGAP19	RGD	RGD:1593044
Mus musculus	ARHGAP19	MGD	MGI:1918335

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