ARHGAP19 - Rho GTPase activating protein 19 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84986

About ARHGAP19

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,222,179-97,292,637 (from NCBI)

This gene has 7 transcripts (splice variants), 251 orthologues and 3 paralogues. Broad expression in testis (RPKM 13.6), bone marrow (RPKM 8.1) and 24 other tissues.

Summary

Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

ARHGAP19 Products (3)

mRNA Protein Name
NM_001204300.2 NP_001191229.1 rho GTPase-activating protein 19 isoform 2
NM_001256423.2 NP_001243352.1 rho GTPase-activating protein 19 isoform 3
NM_032900.6 NP_116289.4 rho GTPase-activating protein 19 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP19 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (125 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 19

  • putative RhoGAP protein

Related Diseases

Diseases Alias
Endometrial Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Endometrium

  • Adenosquamous Carcinoma Of The Endometrium

  • Endometrial Adenosquamous Cancer

  • Endometrial Adenosquamous Cell Carcinoma
Malignant Otitis Externa

  • Necrotising Otitis Externa

  • Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS00919 ARHGAP19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP19 RGD RGD:1593044
Mus musculus ARHGAP19 MGD MGI:1918335