SLC43A1 - solute carrier family 43 member 1 Gene

Also Known as LAT3; PB39; POV1; R00504

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8501

About SLC43A1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,484,534-57,515,702 (from NCBI)

This gene has 10 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in pancreas (RPKM 25.5), liver (RPKM 24.1) and 24 other tissues.

Summary

SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral Amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

SLC43A1 Products (2)

mRNA Protein Name
NM_001198810.2 NP_001185739.1 large neutral amino acids transporter small subunit 3
NM_003627.6 NP_003618.1 large neutral amino acids transporter small subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-isoleucine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12930836 GOA
enables L-leucine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12930836 GOA
enables L-valine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12930836 GOA
enables neutral L-amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
12930836 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in L-leucine transport IDA
IDA: Inferred from direct assay
12930836 GOA
involved in L-valine transmembrane transport IDA
IDA: Inferred from direct assay
12930836 GOA
involved in isoleucine transport IDA
IDA: Inferred from direct assay
12930836 GOA
acts upstream of or within negative regulation of L-leucine import across plasma membrane IDA
IDA: Inferred from direct assay
26305885 GOA
acts upstream of or within negative regulation of amino acid transport IDA
IDA: Inferred from direct assay
26305885 GOA
involved in neutral amino acid transport IDA
IDA: Inferred from direct assay
12930836 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19443642 GOA
located in podocyte foot IDA
IDA: Inferred from direct assay
19443642 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC43A1 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (76 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

large neutral amino acids transporter small subunit 3

  • L-type amino acid transporter 3

SLC43A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC43A1 O75387 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra
SLC43A1 O75387 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
SLC43A1 O75387 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Encephalomalacia
Seminoma

  • Seminoma, Pure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13248 SLC43A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC43A1 RGD RGD:1308229
Canis familiaris SLC43A1 VGNC VGNC:46415
Felis catus SLC43A1 VGNC VGNC:68971
Mus musculus SLC43A1 MGD MGI:1931352
Macaca mulatta SLC43A1 VGNC VGNC:77596
Bos taurus SLC43A1 VGNC VGNC:106933
Others SLC43A1 NCBI