HELZ2 - helicase with zinc finger 2 Gene

Also Known as PDIP-1; PRIC285

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85441

About HELZ2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,558,086-63,574,239 (from NCBI)

This gene has 6 transcripts (splice variants), 170 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 6.7), bone marrow (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HELZ2 Products (2)

mRNA Protein Name
NM_001037335.2 NP_001032412.2 helicase with zinc finger domain 2 isoform 1
NM_033405.3 NP_208384.3 helicase with zinc finger domain 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA helicase activity IDA
IDA: Inferred from direct assay
37602378 GOA
enables exoribonuclease II activity IDA
IDA: Inferred from direct assay
37602378 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
16239304 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16239304 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16239304 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
37602378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HELZ2 Protein Structure

AAA_11

AAA_11: AAA domain (540 - 705)

AAA_12

AAA_12: AAA domain (713 - 915)

RNB

RNB: RNB domain (1334 - 1691)

AAA_11

AAA_11: AAA domain (2152 - 2398)

AAA_12

AAA_12: AAA domain (2406 - 2611)

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  • 2649 a.a.
Protein Preferred Names Protein Names

helicase with zinc finger domain 2

  • ATP-dependent helicase PRIC285

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06119 HELZ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HELZ2 VGNC VGNC:41653
Macaca mulatta HELZ2 VGNC VGNC:73258
Felis catus HELZ2 VGNC VGNC:82419
Mus musculus HELZ2 MGD MGI:2385169
Rattus norvegicus HELZ2 RGD RGD:1306056
Others HELZ2 NCBI