STC2 - stanniocalcin 2 Gene

Also Known as STC-2; STCRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8614

About STC2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:173,314,723-173,328,414 (from NCBI)

This gene has 5 transcripts (splice variants), 260 orthologues and 1 paralogue. Biased expression in placenta (RPKM 12.8), thyroid (RPKM 5.0) and 12 other tissues.

Summary

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by Casein Kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

STC2 Products (1)

mRNA Protein Name
NM_003714.3 NP_003705.1 stanniocalcin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IDA
IDA: Inferred from direct assay
22503972 GOA
enables heme binding IDA
IDA: Inferred from direct assay
22503972 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
15486227 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
9753616 GOA
involved in regulation of hormone biosynthetic process IDA
IDA: Inferred from direct assay
9753616 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22503972 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22503972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STC2 Protein Structure

Stanniocalcin

Stanniocalcin: Stanniocalcin family (8 - 218)

  • 0
  • 100
  • 200
  • 302 a.a.
Protein Preferred Names Protein Names

stanniocalcin-2

  • STC-related protein

Recombinant STC2 Proteins

Cat. No. Product Name Accession Purity
HY-P76095 STC2/Stanniocalcin-2 Protein, Human (HEK293, Fc) O76061 (T25-R302) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P76096 STC2/Stanniocalcin-2 Protein, Human (HEK293, His) O76061 (T25-R302) ≥ 95%, as determined by reducing SDS-PAGE.

STC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87095 Stanniocalcin 2/STC-2 Antibody (YA6788) WB, IP Human

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13904 STC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17649 Stc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24109 Stc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STC2 RGD RGD:621777
Mus musculus STC2 MGD MGI:1316731
Felis catus STC2 VGNC VGNC:102337
Macaca mulatta STC2 VGNC VGNC:77910
Bos taurus STC2 VGNC VGNC:35378
Canis familiaris STC2 VGNC VGNC:46896
Others STC2 NCBI