TNFRSF10C - TNF receptor superfamily member 10c Gene

Homo sapiens

Also known as LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR

Gene ID: 8794 | Gene type: protein coding

About TNFRSF10C

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,102,921-23,117,445 (from NCBI)

This gene has 3 transcripts (splice variants), 583 orthologues and 21 paralogues. Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing Apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced Apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most Cancer cell lines, which may explain the specific sensitivity of Cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

TNFRSF10C Products(1)

mRNA	Protein	Name
NM_003841.5	NP_003832.3	tumor necrosis factor receptor superfamily member 10C precursor

TNFRSF10C Protein Structure

TNFR_c6

0
100
200
259 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 10C

TNF-related apoptosis-inducing ligand receptor 3

Recombinant TNFRSF10C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70815	TNFRSF10C Protein, Human (HEK293, His)	O14798 (A26-A221)	≥95%
HY-P71980	TNFRSF10C Protein, Human (HEK 293, His-hFc)	O14798 (A26-A221)	≥95%
HY-P72278	TNFRSF10C, Human (HEK 293, His)	O14798 (A26-A221)	≥95%
HY-P76860	TNFRSF10C Protein, Human (210a.a, HEK293, His)	O14798 (A26-P235)	≥95%

Related Diseases

Diseases

Alias

46,Xy Sex Reversal 8

SRXY8	Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase
Tdd	46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency
46xy Sex Reversal 8	46xy Sex Reversal 8, Modifier Of
Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Cerebrovascular Benign Neoplasm

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14797	TNFRSF10C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF10C	MGD	MGI:1341090
Rattus norvegicus	TNFRSF10C	RGD	RGD:1586688
Others	TNFRSF10C	NCBI

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