TNFRSF10C - TNF receptor superfamily member 10c Gene

Also Known as LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8794

About TNFRSF10C

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,102,921-23,117,445 (from NCBI)

This gene has 3 transcripts (splice variants), 583 orthologues and 21 paralogues. Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing Apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced Apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most Cancer cell lines, which may explain the specific sensitivity of Cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

TNFRSF10C Products (1)

mRNA	Protein	Name
NM_003841.5	NP_003832.3	tumor necrosis factor receptor superfamily member 10C precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF10C Protein Structure

TNFR_c6

0
100
200
259 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 10C	TNF-related apoptosis-inducing ligand receptor 3

TNFRSF10C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF10C	O14798	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	CYB5R3	Homo sapiens	P00387	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	TNFRSF10C	O14798	SYAP1	Homo sapiens	Q96A49	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	SYAP1	Homo sapiens	Q96A49	Y2H Array	32296183
Intra	TNFRSF10C	O14798	SYAP1	Homo sapiens	Q96A49	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TNFRSF10C	O14798	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TNFRSF10C	O14798	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	TNFRSF10C	O14798	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TNFRSF10C	O14798	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	ASZ1	Homo sapiens	Q8WWH4	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	ASZ1	Homo sapiens	Q8WWH4	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	ASZ1	Homo sapiens	Q8WWH4	Y2H Array	32296183
Intra	TNFRSF10C	O14798	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TNFRSF10C	O14798	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TNFRSF10C	O14798	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	TNFRSF10C	O14798	SLC30A4	Homo sapiens	O14863	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TNFRSF10C	O14798	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	MGST1	Homo sapiens	P10620	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	MGST1	Homo sapiens	P10620	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	MGST1	Homo sapiens	P10620	Y2H Array	32296183
Intra	TNFRSF10C	O14798	GPR37L1	Homo sapiens	O60883	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	TNFRSF10C	O14798	DNAJC1	Homo sapiens	Q96KC8	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	DNAJC1	Homo sapiens	Q96KC8	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	DNAJC1	Homo sapiens	Q96KC8	Y2H Array	32296183
Intra	TNFRSF10C	O14798	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	SGTA	Homo sapiens	O43765	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	TNFRSF10C	O14798	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	TNFRSF10C	O14798	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	KCNK5	Homo sapiens	O95279	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	TNFRSF10C	O14798	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TNFRSF10C	O14798	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TNFRSF10C	O14798	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	COQ9	Homo sapiens	O75208	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TNFRSF10C	O14798	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	TNFRSF10C	O14798	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TNFRSF10C	O14798	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TNFRSF10C	O14798	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TNFRSF10C	O14798	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TNFRSF10C	O14798	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF10C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70815	TNFRSF10C Protein, Human (HEK293, His)	O14798 (A26-A221)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76860	TNFRSF10C Protein, Human (210a.a, HEK293, His)	O14798 (A26-P235)	≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF10C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810754	DcR1 Antibody (YA9997)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
46,Xy Sex Reversal 8	SRXY8 Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase Tdd 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency 46xy Sex Reversal 8 46xy Sex Reversal 8, Modifier Of Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cerebrovascular Benign Neoplasm
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14797	TNFRSF10C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF10C	MGD	MGI:1341090
Rattus norvegicus	TNFRSF10C	RGD	RGD:1586688
Others	TNFRSF10C	NCBI