IL18RAP - interleukin 18 receptor accessory protein Gene

Also Known as ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8807

About IL18RAP

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,418,621-102,452,565 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 26.2), appendix (RPKM 5.0) and 4 other tissues.

Summary

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

IL18RAP Products (5)

mRNA Protein Name
NM_001393486.1 NP_001380415.1 interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393487.1 NP_001380416.1 interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393488.1 NP_001380417.1 interleukin-18 receptor accessory protein isoform 2
NM_001393489.1 NP_001380418.1 interleukin-18 receptor accessory protein isoform 2
NM_003853.4 NP_003844.1 interleukin-18 receptor accessory protein isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
25500532 GOA
enables interleukin-18 receptor activity IDA
IDA: Inferred from direct assay
25500532 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-18-mediated signaling pathway IDA
IDA: Inferred from direct assay
25500532 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
25500532 GOA
Cellular Component GO Annotation Evidence References Source
part of interleukin-18 receptor complex IDA
IDA: Inferred from direct assay
25500532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL18RAP Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (177 - 228)

Ig_2

Ig_2: Immunoglobulin domain (262 - 352)

TIR

TIR: TIR domain (410 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
Protein Preferred Names Protein Names

interleukin-18 receptor accessory protein

  • CD218 antigen-like family member B

IL18RAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL18RAP O95256 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
IL18RAP O95256 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
IL18RAP O95256 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL18RAP Proteins

Cat. No. Product Name Accession Purity
HY-P72573 IL-18R beta/IL-1R7 Protein, Human (HEK293, His) O95256-1 (F20-R356) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76425 IL-18R beta/IL-1R7 Protein, Human (HEK293, Fc) O95256-1 (F20-G357) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Diseases

Diseases Alias
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Inflammatory Bowel Disease 5

  • IBD5
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20633 Il18rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27142 Il18rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992238 Anti-IL-18RAP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IL18RAP VGNC VGNC:73715
Felis catus IL18RAP VGNC VGNC:80121
Rattus norvegicus IL18RAP RGD RGD:727867
Bos taurus IL18RAP VGNC VGNC:30128
Canis familiaris IL18RAP VGNC VGNC:41954
Mus musculus IL18RAP MGD MGI:1338888
Others IL18RAP NCBI