SLC25A21 - solute carrier family 25 member 21 Gene

Also Known as ODC; ODC1; MTDPS18

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 89874

About SLC25A21

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,677,921-37,172,606 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 49 paralogues and is associated with 1 phenotype. Biased expression in esophagus (RPKM 5.4), salivary gland (RPKM 2.6) and 13 other tissues.

Summary

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

SLC25A21 Products (2)

mRNA Protein Name
NM_001171170.2 NP_001164641.1 mitochondrial 2-oxodicarboxylate carrier isoform 2
NM_030631.4 NP_085134.1 mitochondrial 2-oxodicarboxylate carrier isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: Inferred from direct assay
11083877 GOA
enables alpha-ketoglutarate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
29517768 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in mitochondrial alpha-ketoglutarate transmembrane transport IMP
IMP: Inferred from mutant phenotype
29517768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A21 Protein Structure

Mito_carr

Mito_carr: Mitochondrial carrier protein (14 - 101)

Mito_carr

Mito_carr: Mitochondrial carrier protein (110 - 198)

Mito_carr

Mito_carr: Mitochondrial carrier protein (206 - 297)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

mitochondrial 2-oxodicarboxylate carrier

  • mitochondrial 2-oxoadipate carrier

関連疾患

Diseases Alias
Mitochondrial Dna Depletion Syndrome 18

  • MTDPS18
Mitochondrial Dna Depletion Syndrome

  • Mtdna Depletion Syndrome
Alpha-Aminoadipic And Alpha-Ketoadipic Aciduria

  • 2-Aminoadipic 2-Oxoadipic Aciduria

  • Amoxad

  • AAKAD

  • 2-Ketoadipic Aciduria

  • Alpha-Aminoadipic Aciduria

  • Amino Adipic Aciduria

  • Aciduria, 2-Aminoadipic 2-Oxoadipic
Combined D-2- And L-2-Hydroxyglutaric Aciduria

  • D,L-2-Hydroxyglutaric Aciduria

  • D2L2AD

  • Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia

  • Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria

  • D,L-2-Hga

  • D,L-2-Hydroxyglutaric Acidemia

  • Combined D,L-2-Hydroxyglutaric Aciduria
Synpolydactyly

  • Syndactyly Type 2

  • Syndactyly, Type 2

  • Spd
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13102 SLC25A21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus SLC25A21 VGNC VGNC:65263
Canis familiaris SLC25A21 VGNC VGNC:46300
Mus musculus SLC25A21 MGD MGI:2445059
Macaca mulatta SLC25A21 VGNC VGNC:77475
Bos taurus SLC25A21 VGNC VGNC:34749
Rattus norvegicus SLC25A21 RGD RGD:621444
Others SLC25A21 NCBI