SLC25A21 - solute carrier family 25 member 21 Gene

Homo sapiens

Also known as ODC; ODC1; MTDPS18

Gene ID: 89874 | Gene type: protein coding

About SLC25A21

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,677,921-37,172,606 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 49 paralogues and is associated with 1 phenotype. Biased expression in esophagus (RPKM 5.4), salivary gland (RPKM 2.6) and 13 other tissues.

Summary

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

SLC25A21 Products(2)

mRNA	Protein	Name
NM_001171170.2	NP_001164641.1	mitochondrial 2-oxodicarboxylate carrier isoform 2
NM_030631.4	NP_085134.1	mitochondrial 2-oxodicarboxylate carrier isoform 1

SLC25A21 Protein Structure

Mito_carr

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

mitochondrial 2-oxodicarboxylate carrier

mitochondrial 2-oxoadipate carrier

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 18

MTDPS18

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Alpha-Aminoadipic And Alpha-Ketoadipic Aciduria

2-Aminoadipic 2-Oxoadipic Aciduria	Amoxad
AAKAD	2-Ketoadipic Aciduria
Alpha-Aminoadipic Aciduria	Amino Adipic Aciduria
Aciduria, 2-Aminoadipic 2-Oxoadipic

Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria	D2L2AD
Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia	Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria
D,L-2-Hga	D,L-2-Hydroxyglutaric Acidemia
Combined D,L-2-Hydroxyglutaric Aciduria

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13102	SLC25A21 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC25A21	VGNC	VGNC:65263
Canis familiaris	SLC25A21	VGNC	VGNC:46300
Mus musculus	SLC25A21	MGD	MGI:2445059
Macaca mulatta	SLC25A21	VGNC	VGNC:77475
Bos taurus	SLC25A21	VGNC	VGNC:34749
Rattus norvegicus	SLC25A21	RGD	RGD:621444

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