TM4SF5 - transmembrane 4 L six family member 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9032

About TM4SF5

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,771,886-4,783,211 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 71.1), small intestine (RPKM 65.8) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

TM4SF5 Products (1)

mRNA Protein Name
NM_003963.3 NP_003954.2 transmembrane 4 L6 family member 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arginine binding IMP
IMP: Inferred from mutant phenotype
30956113 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30956113 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
20399237 GOA
Cellular Component GO Annotation Evidence References Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
30956113 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
30956113 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM4SF5 Protein Structure

L6_membrane

L6_membrane: L6 membrane protein (1 - 191)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

transmembrane 4 L6 family member 5

  • tetraspan transmembrane protein L6H

TM4SF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TM4SF5 O14894 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
TM4SF5 O14894 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
TM4SF5 O14894 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14610 TM4SF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TM4SF5 RGD RGD:1308709
Bos taurus TM4SF5 VGNC VGNC:35907
Macaca mulatta TM4SF5 VGNC VGNC:99301
Mus musculus TM4SF5 MGD MGI:1922854
Felis catus TM4SF5 VGNC VGNC:99559
Canis familiaris TM4SF5 VGNC VGNC:47410
Others TM4SF5 NCBI