DDX60L - DExD/H-box 60 like Gene
Species: Homo sapiens
About DDX60L
This gene has 16 transcripts (splice variants), 29 orthologues and 8 paralogues. Ubiquitous expression in appendix (RPKM 7.8), bone marrow (RPKM 6.5) and 24 other tissues.
Summary
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in Cell Culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
DDX60L Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001012967.3 | NP_001012985.2 | probable ATP-dependent RNA helicase DDX60-like isoform 1 |
| NM_001291510.2 | NP_001278439.1 | probable ATP-dependent RNA helicase DDX60-like isoform 2 |
| NM_001345927.2 | NP_001332856.1 | probable ATP-dependent RNA helicase DDX60-like isoform 3 |
| NM_001378069.1 | NP_001364998.1 | probable ATP-dependent RNA helicase DDX60-like isoform 4 |
| NM_001378070.1 | NP_001364999.1 | probable ATP-dependent RNA helicase DDX60-like isoform 4 |
| NM_001378071.1 | NP_001365000.1 | probable ATP-dependent RNA helicase DDX60-like isoform 4 |
| NM_001378072.1 | NP_001365001.1 | probable ATP-dependent RNA helicase DDX60-like isoform 3 |
DDX60L Protein Structure
DEAD: DEAD/DEAH box helicase (747 - 902)
Helicase_C: Helicase conserved C-terminal domain (1244 - 1314)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1706 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
probable ATP-dependent RNA helicase DDX60-like |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lip Cancer |
|
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| Hepatitis C Virus |
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Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS03665 | DDX60L Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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