2. Gene
  3. ARRDC4 - arrestin domain containing 4 Gene

ARRDC4 - arrestin domain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 91947 | Gene type: protein coding

About ARRDC4

Cytogenetic location: 15q26.2 Genomic coordinates (GRCh38): 15:97,960,703-97,973,833 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC4 Products(1)

mRNA Protein Name
NM_183376.3 NP_899232.2 arrestin domain-containing protein 4

ARRDC4 Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (24 - 169)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (192 - 317)

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  • 418 a.a.
Protein Preferred Names Protein Names

arrestin domain-containing protein 4

Related Diseases

Diseases Alias
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124418 SBI-477 Inhibitor ≥98.0% Unkown
HY-122682 SBI-993 98.67% Unkown
HY-RS01033 ARRDC4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARRDC4 VGNC VGNC:107995
Rattus norvegicus ARRDC4 RGD RGD:1311763
Canis familiaris ARRDC4 VGNC VGNC:38141
Mus musculus ARRDC4 MGD MGI:1913662
Bos taurus ARRDC4 VGNC VGNC:26174
Felis catus ARRDC4 VGNC VGNC:59946