ARRDC4 - arrestin domain containing 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91947

About ARRDC4

Cytogenetic location: 15q26.2 Genomic coordinates (GRCh38): 15:97,960,703-97,973,833 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC4 Products (1)

mRNA Protein Name
NM_183376.3 NP_899232.2 arrestin domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23236378 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
28594402 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
28594402 GOA
acts upstream of or within positive regulation of ubiquitin-protein transferase activity IPI
IPI: Inferred from physical interaction
23236378 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
28594402 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
23236378 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23236378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRDC4 Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (24 - 169)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (192 - 317)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

arrestin domain-containing protein 4

ARRDC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARRDC4 Q8NCT1 AVPR2 Homo sapiens P30518
Anti Tag CoIP
23236378
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

  • Schinzel Phocomelia Syndrome

  • Aarrs

  • Limb/Pelvis-Hypoplasia/Aplasia Syndrome

  • LPHAS

  • Schinzel Type Phocomelia

  • Absence Of Ulna And Fibula With Severe Limb Deficiency

  • Al-Awadi/Raas-Rothschild Syndrome

  • Al Awadi-Raas-Rothschild Syndrome

  • Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

  • Aplasia/Hypoplasia Of Limbs And Pelvis

  • Congenital Absence Of Ulna And Fibula

  • Severe Limb Deficit

  • Phocomelia, Schinzel Type

  • Al-Awadi-Raas-Rothschild Syndrome

  • Ulna And Fibula Absence Of With Severe Limb Deficiency

  • Limb Pelvis Hypoplasia Aplasia Syndrome

  • Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

  • Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122682 SBI-993 98.79% Unkown
HY-124418 SBI-477 Inhibitor 98.0% Unkown
HY-RS01033 ARRDC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19500 Arrdc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25994 Arrdc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARRDC4 VGNC VGNC:107995
Rattus norvegicus ARRDC4 RGD RGD:1311763
Canis familiaris ARRDC4 VGNC VGNC:38141
Mus musculus ARRDC4 MGD MGI:1913662
Bos taurus ARRDC4 VGNC VGNC:26174
Felis catus ARRDC4 VGNC VGNC:59946
Others ARRDC4 NCBI