CLEC6A - C-type lectin domain containing 6A Gene

Also Known as CLEC4N; CLECSF10; dectin-2; hDECTIN-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93978

About CLEC6A

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,455,962-8,478,330 (from NCBI)

This gene has 1 transcript (splice variant), 841 orthologues and 14 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust Mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

CLEC6A Products (2)

mRNA Protein Name
NM_001007033.2 NP_001007034.1 C-type lectin domain family 6 member A isoform 1
NM_001317999.2 NP_001304928.1 C-type lectin domain family 6 member A isoform 2

CLEC6A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (97 - 204)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 6 member A

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10

Recombinant CLEC6A Proteins

Cat. No. Product Name Accession Purity
HY-P74201 Dectin-2/CLEC6A Protein, Human (HEK293, Fc) Q6EIG7-1/NP_001007034 (T42-L209) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cryptococcosis

  • Cryptococcus Neoformans Infection

  • Torulosis

  • Busse-Buschke'S Disease

  • Cryptococcal Infection

  • European Cryptococcosis

  • Torula

  • Infection By Cryptococcus Neoformans

  • Cryptococcosis Infection

  • European Blastomycosis

  • European Blastomycotic Infection

  • European Blastomycoses Infection

  • Torula Histolytica Infection
Subcutaneous Mycosis

  • Subcutaneous Fungal Disease
Tinea Profunda

  • Deep Seated Dermatophytosis

  • Granuloma Trichophyticum

  • Majocchi'S Granuloma
Dermatophytosis

  • Tinea

  • Dermatophytosis, Unspecified

  • Ringworm

  • Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

  • Cutaneous Mycosis

  • Dermal Mycosis

  • Superficial Mycosis, Unspecified

  • Fungus Infection Of Skin

  • Skin Mycosis

  • Dermatitis Fungoid

  • Fungal Dermatitis

  • Fungal Dermatosis

  • Mycotic Infection Of Skin
Blastomycosis

  • Gilchrist'S Disease

  • North American Blastomycosis

  • Blastomyces Dermatitidis Infection

  • Blastomycotic Infection

  • Infection By Blastomyces Dermatitidis

  • Gilchrist Disease

  • Chicago Disease

  • Chicago Disease Or Disorder

  • Blastomycosis, Unspecified

  • Blastomyces Infection
Primary Systemic Mycosis
Phaeohyphomycosis

  • Infection By Dematiacious Fungi

  • Phaehyphomycosis

  • Phaeomycosis

  • Pheohyphomycosis

  • Infection By Dematiacious Fungi [Phaehyphomycosis]

  • Dematiaceous Fungal Infection
Fungal Infectious Disease

  • Mycoses

  • Mycosis
Opportunistic Mycosis

  • Opportunistic Mycoses

  • Opportunistic Systemic Mycoses
Tinea Corporis

  • Dermatophytosis Of The Body

  • Dermatophytosis Of The Trunk
Vulvovaginal Candidiasis

  • Candidiasis Of Vulva And Vagina

  • Candidiasis, Vulvovaginal

  • Candidal Vulvovaginitis

  • Candidal: Cervix

  • Monilial Vulvovaginitis

  • Candidiasis Vulvovaginal
Superficial Mycosis

  • Piedra

  • Steroid-Modified Tinea Infection
Chromoblastomycosis

  • Chromomycosis

  • Mossy Foot Disease

  • Verrucous Dermatitis

  • Fonseca Disease

  • Pedroso Disease

  • Drechslera Hawaiiensis

  • Drechslera Infection
Invasive Aspergillosis

  • Aspergillosis Invasive
Coccidioidomycosis

  • Valley Fever

  • Primary Extrapulmonary Coccidioidomycosis

  • Coccidioides Immitis Infection

  • Coccidiosis

  • Coccidioides Infection

  • Coccidioidomycosis, Unspecified

  • San Joaquin Fever

  • California Disease

  • Desert Fever

  • Desert Rheumatism

  • San Joaquin Valley Fever

  • Enteric Coccidiosis

  • Primary Pulmonary Coccidioidomycosis

  • Acute Coccidioidomycosis

  • Posadas Wernicke Disease
Tinea Pedis

  • Athlete'S Foot

  • Dermatophytosis Of Foot

  • Ringworm Of Foot

  • Moccasin Foot
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Pityriasis Versicolor

  • Tinea Versicolor

  • Infection By Pityrosporum Furfur
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Tinea Capitis

  • Dermatophytosis Of Scalp

  • Scalp Ringworm

  • Dermatophytosis Of Scalp Or Beard

  • Tinea Capitis Due To Trichophyton Rubrum

  • Trichophyton Rubrum Tinea Capitis
Sporotrichosis

  • Rose Gardener'S Disease
Oral Candidiasis

  • Thrush

  • Candidiasis Of Mouth

  • Oral Moniliasis

  • Thrush, Oral

  • Candidiasis, Oral

  • Oral Thrush

  • Candidiasis

  • Equine Thrush
Tinea Imbricata

  • Kerion Celsi

  • Trichophyton Infection

  • Tinea Imbricata, Susceptibility To

  • Susceptibility To Tinea Imbricata

  • Tinea Capitis Profunda

  • Trichophytia Profunda Barbae

  • Trichophytia Profunda Capitis

  • Tinea Capitis
Tinea Cruris

  • Dermatophytosis Of Groin & Perianal Area

  • Dermatophytosis Of Groin And Perianal Area

  • Dhobie Itch

  • Tinea Of Perianal Region
Histoplasmosis

  • Darling Disease

  • Reticuloendotheliosis, X-Linked

  • Infection By Histoplasma Capsulatum

  • Histoplasma Infection

  • Reticuloendothelial Cytomycosis

  • Cytomycosis

  • Darling Histoplasmosis

  • African Histoplasmosis

  • Histoplasmosis Duboisii
Fungal Meningitis

  • Meningitis, Fungal

  • Mycotic Meningitis
Allergic Bronchopulmonary Aspergillosis

  • Aspergillosis, Allergic Bronchopulmonary

  • Abpa

  • Allergic Bronchopulmonary Mycosis

  • Hinson-Pepys Disease

  • Pulmonary Aspergillus Disease

  • Allergic Aspergillosis

  • Aspergillosis Allergic Bronchopulmonary
Cutaneous Candidiasis

  • Candidiasis, Cutaneous
Vaginal Disease

  • Vaginal Diseases
Cryptococcal Meningitis

  • Meningitis, Cryptococcal

  • Meningitis Cryptococcal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02799 CLEC6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLEC6A RGD RGD:1359505
Mus musculus CLEC6A MGD MGI:1861231
Macaca mulatta CLEC6A VGNC VGNC:71179
Bos taurus CLEC6A VGNC VGNC:27436
Others CLEC6A NCBI