CLEC6A - C-type lectin domain containing 6A Gene

Homo sapiens

Also known as CLEC4N; CLECSF10; dectin-2; hDECTIN-2

Gene ID: 93978 | Gene type: protein coding

About CLEC6A

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,455,962-8,478,330 (from NCBI)

This gene has 1 transcript (splice variant), 841 orthologues and 14 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust Mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

CLEC6A Products(2)

mRNA	Protein	Name
NM_001007033.2	NP_001007034.1	C-type lectin domain family 6 member A isoform 1
NM_001317999.2	NP_001304928.1	C-type lectin domain family 6 member A isoform 2

CLEC6A Protein Structure

Lectin_C

0
100
209 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 6 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10

Recombinant CLEC6A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74201	Dectin-2/CLEC6A Protein, Human (HEK293, Fc)	Q6EIG7 (T42-L209)	≥95%

Related Diseases

Diseases

Alias

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Primary Systemic Mycosis

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Fungal Infectious Disease

Mycoses

Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Invasive Aspergillosis

Aspergillosis Invasive

Coccidioidomycosis

Valley Fever	Primary Extrapulmonary Coccidioidomycosis
Coccidioides Immitis Infection	Coccidiosis
Coccidioides Infection	Coccidioidomycosis, Unspecified
San Joaquin Fever	California Disease
Desert Fever	Desert Rheumatism
San Joaquin Valley Fever	Enteric Coccidiosis
Primary Pulmonary Coccidioidomycosis	Acute Coccidioidomycosis
Posadas Wernicke Disease

Tinea Pedis

Athlete'S Foot	Dermatophytosis Of Foot
Ringworm Of Foot	Moccasin Foot

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

Sporotrichosis

Rose Gardener'S Disease

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Tinea Imbricata

Kerion Celsi	Trichophyton Infection
Tinea Imbricata, Susceptibility To	Susceptibility To Tinea Imbricata
Tinea Capitis Profunda	Trichophytia Profunda Barbae
Trichophytia Profunda Capitis	Tinea Capitis

Tinea Cruris

Dermatophytosis Of Groin & Perianal Area	Dermatophytosis Of Groin And Perianal Area
Dhobie Itch	Tinea Of Perianal Region

Histoplasmosis

Darling Disease	Reticuloendotheliosis, X-Linked
Infection By Histoplasma Capsulatum	Histoplasma Infection
Reticuloendothelial Cytomycosis	Cytomycosis
Darling Histoplasmosis	African Histoplasmosis
Histoplasmosis Duboisii

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary	Abpa
Allergic Bronchopulmonary Mycosis	Hinson-Pepys Disease
Pulmonary Aspergillus Disease	Allergic Aspergillosis
Aspergillosis Allergic Bronchopulmonary

Cutaneous Candidiasis

Candidiasis, Cutaneous

Vaginal Disease

Vaginal Diseases

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02799	CLEC6A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLEC6A	RGD	RGD:1359505
Mus musculus	CLEC6A	MGD	MGI:1861231
Macaca mulatta	CLEC6A	VGNC	VGNC:71179
Bos taurus	CLEC6A	VGNC	VGNC:27436
Others	CLEC6A	NCBI

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