Hrg - histidine-rich glycoprotein Gene

Also Known as Hprg; Hrgp; D16jh2; D18020

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94175

Summary

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of blood vessel remodeling; and positive regulation of immune response to tumor cell. Acts upstream of or within several processes, including heme export; negative regulation of fibrinolysis; and regulation of transcription from RNA polymerase II promoter in response to iron. Located in endolysosome and phagolysosome membrane. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Hrg Products (1)

mRNA Protein Name
NM_053176.2 NP_444406.2 histidine-rich glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15748999 MGI
enables serine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
15869579 MGI
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
18797515 MGI
involved in defense response to fungus IMP
IMP: Inferred from mutant phenotype
18797515 MGI
acts upstream of fibrinolysis IMP
IMP: Inferred from mutant phenotype
15869579 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
22348394 MGI
involved in negative regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
22348394 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
22348394 MGI
acts upstream of or within negative regulation of fibrinolysis IMP
IMP: Inferred from mutant phenotype
15869579 MGI
involved in positive regulation of blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
22348394 MGI
involved in positive regulation of immune response to tumor cell IMP
IMP: Inferred from mutant phenotype
22348394 MGI
involved in regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
15869579 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22348394 MGI
involved in regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
15869579 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histidine-rich glycoprotein

  • histidine-proline-rich glycoprotein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06358 HRG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176070 HRG038 Inhibitor / Unkown
HY-RS16312 NRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16611 Nrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16937 Hrg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23380 Hrg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hrg NCBI NCBI:3273