VGLL4 - vestigial like family member 4 Gene

Also Known as VGL-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9686

About VGLL4

Cytogenetic location: 3p25.3-p25.2 Genomic coordinates (GRCh38): 3:11,556,067-11,721,815 (from NCBI)

This gene has 18 transcripts (splice variants) and 267 orthologues. Ubiquitous expression in ovary (RPKM 26.1), thyroid (RPKM 18.5) and 25 other tissues.

Summary

Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VGLL4 Products (6)

mRNA Protein Name
NM_001128219.3 NP_001121691.1 transcription cofactor vestigial-like protein 4 isoform a
NM_001128220.3 NP_001121692.1 transcription cofactor vestigial-like protein 4 isoform c
NM_001128221.3 NP_001121693.1 transcription cofactor vestigial-like protein 4 isoform d
NM_001284390.2 NP_001271319.1 transcription cofactor vestigial-like protein 4 isoform e
NM_001284391.1 NP_001271320.1 transcription cofactor vestigial-like protein 4 isoform f
NM_014667.4 NP_055482.2 transcription cofactor vestigial-like protein 4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
28051067 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
28051067 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
28051067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL4 Protein Structure

VGLL4

VGLL4: Transcription cofactor vestigial-like protein 4 (10 - 224)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 4

  • Vestigial-like 4

VGLL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Validated Y2H
32296183
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Anti Tag CoIP
33961781
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Y2H Prey Pooling
32296183
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Y2H Array
32296183
Intra
VGLL4 Q14135 TEAD4 Homo sapiens Q15561
BLI
24525233
Intra
VGLL4 Q14135 TEAD4 Homo sapiens Q15561
Anti Tag CoIP
33961781
Intra
VGLL4 Q14135 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
VGLL4 Q14135 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Validated Y2H
32296183
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Y2H Array
32296183
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137479 TEAD-IN-1 Inhibitor 99.43% Unkown
HY-RS15647 VGLL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22913 Vgll4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29427 Vgll4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VGLL4 VGNC VGNC:36793
Canis familiaris VGLL4 VGNC VGNC:48260
Macaca mulatta VGLL4 VGNC VGNC:79755
Rattus norvegicus VGLL4 RGD RGD:1311653
Mus musculus VGLL4 MGD MGI:2652840
Felis catus VGLL4 VGNC VGNC:80753
Others VGLL4 NCBI