ZBTB40 - zinc finger and BTB domain containing 40 Gene

Also Known as ZNF923

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9923

About ZBTB40

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,428,909-22,531,154 (from NCBI)

This gene has 5 transcripts (splice variants), 179 orthologues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 6.6), spleen (RPKM 6.6) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to DNA damage stimulus. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB40 Products (3)

mRNA Protein Name
NM_001083621.2 NP_001077090.1 zinc finger and BTB domain-containing protein 40 isoform a
NM_001330398.2 NP_001317327.1 zinc finger and BTB domain-containing protein 40 isoform b
NM_014870.4 NP_055685.3 zinc finger and BTB domain-containing protein 40 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28169274 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
17525332 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15302935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB40 Protein Structure

BTB

BTB: BTB/POZ domain (18 - 114)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (809 - 830)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (851 - 874)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (908 - 931)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (950 - 973)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (978 - 1000)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1006 - 1029)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1047 - 1069)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1135 - 1158)

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  • 1239 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 40

Related Diseases

Diseases Alias
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15975 ZBTB40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZBTB40 RGD RGD:1309866
Macaca mulatta ZBTB40 VGNC VGNC:79771
Canis familiaris ZBTB40 VGNC VGNC:48535
Bos taurus ZBTB40 VGNC VGNC:37079
Mus musculus ZBTB40 MGD MGI:2682254
Felis catus ZBTB40 VGNC VGNC:67170
Others ZBTB40 NCBI