1. Gene
  2. KIF14 - kinesin family member 14 Gene

KIF14 - kinesin family member 14 Gene

Homo sapiens

Also known as MKS12; MCPH20

Gene ID: 9928 | Gene type: protein coding

About KIF14

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,551,497-200,620,751 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 41 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues.

Summary

This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

KIF14 Products(15)

mRNA Protein Name
XM_047436199.1 XP_047292155.1 kinesin-like protein KIF14 isoform X6
XM_047436184.1 XP_047292140.1 kinesin-like protein KIF14 isoform X2
XM_011510235.3 XP_011508537.1 kinesin-like protein KIF14 isoform X5
XM_011510233.3 XP_011508535.1 kinesin-like protein KIF14 isoform X2
XM_011510232.3 XP_011508534.1 kinesin-like protein KIF14 isoform X1
XM_047436195.1 XP_047292151.1 kinesin-like protein KIF14 isoform X4
XM_017003006.2 XP_016858495.1 kinesin-like protein KIF14 isoform X3
XM_017003007.2 XP_016858496.1 kinesin-like protein KIF14 isoform X7
XM_047436181.1 XP_047292137.1 kinesin-like protein KIF14 isoform X2
XM_011510231.3 XP_011508533.1 kinesin-like protein KIF14 isoform X1
XM_047436197.1 XP_047292153.1 kinesin-like protein KIF14 isoform X5
XM_047436190.1 XP_047292146.1 kinesin-like protein KIF14 isoform X2
XM_047436198.1 XP_047292154.1 kinesin-like protein KIF14 isoform X5
NM_001305792.1 NP_001292721.1 kinesin-like protein KIF14 isoform 2
NM_014875.3 NP_055690.1 kinesin-like protein KIF14 isoform 1

KIF14 Protein Structure

Kinesin

Kinesin: Kinesin motor domain (364 - 701)

FHA

FHA: FHA domain (826 - 891)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1648 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF14

epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Leukocoria

Leucocoria

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Meckel Syndrome 12

Lethal Fetal Cerebrorenogenitourinary Agenesis/Hypoplasia Syndrome

MKS12

Meckel Syndrome, Type 12

Microcephaly 5, Primary, Autosomal Recessive

MCPH5

Primary Autosomal Recessive Microcephaly 5

Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern

Microcephaly, Primary Autosomal Recessive, 5

Lissencephaly 4

LIS4

Lissencephaly 4 With Microcephaly

Microlissencephaly

Lissencephaly, Type 4

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome

GOSHS

Megacolon-Microcephaly Syndrome

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Bilateral Retinoblastoma
Microcephaly 20, Primary, Autosomal Recessive

MCPH20

Unilateral Retinoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus KIF14 VGNC VGNC:30583
Canis familiaris KIF14 VGNC VGNC:42383
Felis catus KIF14 VGNC VGNC:63103
Mus musculus KIF14 MGD MGI:1098226
Rattus norvegicus KIF14 RGD RGD:1310650
Macaca mulatta KIF14 VGNC VGNC:99990