Sall4 - spalt like transcription factor 4 Gene

Also Known as Tex20; 5730441M18Rik; C330011P20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99377

Summary

This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Sall4 Products (3)

mRNA Protein Name
NM_175303.4 NP_780512.2 sal-like protein 4 isoform a
NM_201395.3 NP_958797.2 sal-like protein 4 isoform b
NM_201396.3 NP_958798.2 sal-like protein 4 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16380715 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
26523946 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
16380715 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
16380715 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16380715 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17060609 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
16790473 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16380715 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
16790473 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
16790473 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
18818376 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16380715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16380715 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
acts upstream of or within tissue development IMP
IMP: Inferred from mutant phenotype
17060609 MGI
acts upstream of or within ventricular septum development IGI
IGI: Inferred from genetic interaction
16790473 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
16790473 MGI
Cellular Component GO Annotation Evidence References Source
located in heterochromatin IDA
IDA: Inferred from direct assay
17295837 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sal-like protein 4

  • sal-like 4

  • zinc finger protein SALL4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144998 NVP-DKY709 Inhibitor 99.66% Unkown
HY-RS21750 Sall4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169348 β-catenin-IN-8 Inhibitor / Unkown
HY-175875 HRZ-01-082-5 Degrader / Unkown
HY-RS12420 SALL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1128213 IKZF2-degrader 2 Degrader / Unkown
HY-W599279 ABS-752 Degrader / Unkown
HY-RS28268 Sall4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sall4 NCBI NCBI:57167