2. Gene
  3. ARHGAP25 - Rho GTPase activating protein 25 Gene

ARHGAP25 - Rho GTPase activating protein 25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KAIA0053; HEL-S-308

Gene ID: 9938 | Gene type: protein coding

About ARHGAP25

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,710,544-68,826,833 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues.

Summary

ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

ARHGAP25 Products(7)

mRNA Protein Name
NM_001007231.3 NP_001007232.2 rho GTPase-activating protein 25 isoform a
NM_001166276.2 NP_001159748.1 rho GTPase-activating protein 25 isoform c
NM_001166277.2 NP_001159749.1 rho GTPase-activating protein 25 isoform d
NM_001364819.1 NP_001351748.1 rho GTPase-activating protein 25 isoform e
NM_001364820.1 NP_001351749.1 rho GTPase-activating protein 25 isoform f
NM_001364821.1 NP_001351750.1 rho GTPase-activating protein 25 isoform g
NM_014882.3 NP_055697.1 rho GTPase-activating protein 25 isoform b

ARHGAP25 Protein Structure

PH

PH: PH domain (48 - 148)

RhoGAP

RhoGAP: RhoGAP domain (178 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 25

epididymis secretory protein Li 308

Related Diseases

Diseases Alias
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00925 ARHGAP25 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARHGAP25 VGNC VGNC:26083
Macaca mulatta ARHGAP25 VGNC VGNC:69921
Rattus norvegicus ARHGAP25 RGD RGD:1562105
Mus musculus ARHGAP25 MGD MGI:2443687
Felis catus ARHGAP25 VGNC VGNC:59882