ARHGAP25 - Rho GTPase activating protein 25 Gene

Also Known as KAIA0053; HEL-S-308

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9938

About ARHGAP25

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,710,544-68,826,833 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues.

Summary

ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

ARHGAP25 Products (7)

mRNA Protein Name
NM_001007231.3 NP_001007232.2 rho GTPase-activating protein 25 isoform a
NM_001166276.2 NP_001159748.1 rho GTPase-activating protein 25 isoform c
NM_001166277.2 NP_001159749.1 rho GTPase-activating protein 25 isoform d
NM_001364819.1 NP_001351748.1 rho GTPase-activating protein 25 isoform e
NM_001364820.1 NP_001351749.1 rho GTPase-activating protein 25 isoform f
NM_001364821.1 NP_001351750.1 rho GTPase-activating protein 25 isoform g
NM_014882.3 NP_055697.1 rho GTPase-activating protein 25 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
26465210 GOA
involved in negative regulation of small GTPase mediated signal transduction IMP
IMP: Inferred from mutant phenotype
26465210 GOA
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
26465210 GOA
Cellular Component GO Annotation Evidence References Source
located in phagocytic cup IDA
IDA: Inferred from direct assay
26465210 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP25 Protein Structure

PH

PH: PH domain (48 - 148)

RhoGAP

RhoGAP: RhoGAP domain (178 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 25

  • epididymis secretory protein Li 308

ARHGAP25 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82404 ARHGAP25 Antibody (YA2149) WB, IHC-P Human, Rat
HY-P82404A ARHGAP25 Antibody (YA2149)(PBS only) WB, IHC-P Human, Rat

Related Diseases

Diseases Alias
Rhabdomyosarcoma 2

  • Alveolar Rhabdomyosarcoma

  • Rhabdomyosarcoma, Alveolar

  • Rhabdomyosarcoma Alveolar

  • RMS2

  • Rmsa

  • Rhabdomyosarcoma 2, Alveolar

  • Alveolar Childhood Rhabdomyosarcoma

  • Arms

  • Rhabdomyosarcoma, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00925 ARHGAP25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARHGAP25 VGNC VGNC:26083
Macaca mulatta ARHGAP25 VGNC VGNC:69921
Rattus norvegicus ARHGAP25 RGD RGD:1562105
Mus musculus ARHGAP25 MGD MGI:2443687
Felis catus ARHGAP25 VGNC VGNC:59882
Others ARHGAP25 NCBI