DLEC1 - DLEC1 cilia and flagella associated protein Gene

Also Known as F56; DLC1; DLC-1; FAP81; CFAP81

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9940

About DLEC1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,039,208-38,124,025 (from NCBI)

This gene has 7 transcripts (splice variants), 152 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 8.8), lung (RPKM 3.8) and 2 other tissues.

Summary

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

DLEC1 Products (3)

mRNA Protein Name
NM_001321153.2 NP_001308082.1 deleted in lung and esophageal cancer protein 1 isoform 3
NM_007335.4 NP_031361.2 deleted in lung and esophageal cancer protein 1 isoform DLEC1-N1
NM_007337.4 NP_031363.2 deleted in lung and esophageal cancer protein 1 isoform DLEC1-S3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
33144677 GOA
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
33144677 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33144677 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to tumor cell IMP
IMP: Inferred from mutant phenotype
30429596 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10213508 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deleted in lung and esophageal cancer protein 1

  • DLEC, cilia and flagella associated protein

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Esophagus Squamous Cell Carcinoma

  • Esophageal Squamous Cell Carcinoma

  • Oesophagus Squamous Cell Carcinoma

  • Scc Of Esophagus

  • Scc Of Oesophagus

  • Squamous Cell Carcinoma Of The Esophagus

  • Escc

  • Esophageal Epidermoid Carcinoma

  • Squamous Cell Esophageal Cancer

  • Squamous Cell Carcinoma Of Esophagus
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Kidney Cancer

  • Renal Cancer

  • Renal Carcinoma

  • Kidney Neoplasm

  • Malignant Neoplasm Of Kidney Except Pelvis

  • Malignant Tumour Of Kidney

  • Kidney Neoplasms

  • Cancer, Kidney

  • Cancer, Renal

  • Malignant Neoplasm Of Kidney

  • Renal Cell Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03795 DLEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DLEC1 VGNC VGNC:61510
Canis familiaris DLEC1 VGNC VGNC:54779
Macaca mulatta DLEC1 VGNC VGNC:71808
Rattus norvegicus DLEC1 RGD RGD:1561649
Mus musculus DLEC1 MGD MGI:2443671
Bos taurus DLEC1 VGNC VGNC:54782
Others DLEC1 NCBI