Globotriaosylsphingosine  (Synonyms: lyso-Gb3)

Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research^[1].

Globotriaosylsphingosine (100 nM, 500 nM; 24 h) reduces KCa3.1 mRNA expression levels and Glo1a1 and Glo3a1 protein levels^[1].
Globotriaosylsphingosine (50-500 nM, 24 h) dose-dependently inhibits fibroblast growth, differentiation into myofibroblasts, and collagen synthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

785.91

C₃₆H₆₇NO₁₇

126550-86-5

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Choi JY, et al. Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Biochem Biophys Res Commun. 2015 Dec 25;468(4):883-8.  [Content Brief]

  [2]. Auray-Blais C, et al. How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? Clin Chim Acta. 2010 Dec 14;411(23-24):1906-14.  [Content Brief]