GMA-839
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics.
For research use only. We do not sell to patients.
- CAS No.: 162882-76-0
- Formula: C21H31F3O3
- Molecular Weight:388.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 162882-76-0
-
Molecular Weight 388.46
-
Formula C21H31F3O3
-
SMILES
FC(F)(F)[C@]1(CC[C@@]2([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC[C@@]2(C1)[H])[H])[H])C(CO)=O)C)[H])[H])O
-
Synonyms
WAY 141839; Co 2-6749
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Vanover KE, et al. Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther. 2000 Oct;295(1):337-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GMA-839 Related Classifications
HY-117955 Related Classifications
Powered by Bioz