hCAIX/XII-IN-5
hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis.
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- CAS No.: 2421127-99-1
- 화학식: C18H13NO3
- 분자량:291.30
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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hCA XII 85.7 nM (Ki) |
hCA IX 93.9 nM (Ki) |
hCAIX/XII-IN-5 (2.36-32.17 μM) treatment shows both anti-proliferative activities to MCF-7 and PANC-1 cells under the normoxic and hypoxic condition[1].
hCAIX/XII-IN-5 (2.69 μM; 24 h) treatment shows accumulation of MCF-7 cells in the Sub-G1 phase and cell arrest in G2-M phase[1].
hCAIX/XII-IN-5 (2.69 μM; 24 h) treatment increases the percent of annexin V-FITC-positive apoptotic cells, including both the early and late apoptotic cells (UR+LR) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and PANC-1 cells
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Concentration:2.36-32.17 μM
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Incubation Time:
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Result:Exerted anti-proliferative activities to MCF-7 and PANC-1 cells (IC50=2.69 μM and 32.17 μM, respectively) under the normoxic condition, and moderate activitits against both MCF-7 and PANC-1 cells (IC50=16.36 μM and 11.78 μM, respectively) under the hypoxic condition.
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Cell Line:MCF-7 cells
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Concentration:2.69 μM
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Incubation Time:24 hours
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Result:Resulted in a significant increase in the percentage of cells at Sub-G1 by 14-folds with significant increase in cell percentage in the G1-M phase by 2.3-folds compared to the control.
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Cell Line:MCF-7 cells
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Concentration:2.69 μM
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Incubation Time:24 hours
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Result:Resulted in a significant increase in the percent of annexin V-FITC-positive apoptotic cells, including both the early (from 0.61% to 6.77%) and late apoptotic (from 0.27% to 14.84%) cells (UR+LR), about 11- and 55-fold increase, respectively, as compared with the control.
Chemical Information
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CAS No. 2421127-99-1
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분자량 291.30
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화학식 C18H13NO3
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SMILES
O=C1C(C(/C=C/NC2=CC=CC=C2)=O)=CC3=C(O1)C=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX/XII-IN-5 Related Classifications
HY-150695 Related Classifications
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