HIV-1 inhibitor-40
HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity.
For research use only. We do not sell to patients.
- CAS No.: 2789676-44-2
- Formula: C25H18N6O2
- Molecular Weight:434.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HIV-1 (WT) 1.9 nM (EC50) |
HIV-1 (K103N) 0.004 μM (EC50) |
HIV-1 (E138K) 0.009 μM (EC50) |
HIV-1 (L100I) 0.019 μM (EC50) |
HIV-1 (Y181C) 0.029 μM (EC50) |
HIV-1 (Y188L) 0.570 μM (EC50) |
CYP2C19 4.51 μM (IC50) |
CYP2C9 5.16 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
120 μM
Compound: 4ab
|
Cytotoxicity against human MT4 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 35649164] |
HIV-1 inhibitor-40 (Compound 4ab) displays inhibitory activity with EC50 values of 0.019 ± 0.005, 0.004 ± 0.001, 0.029 ± 0.007, 0.570 ± 0.099 and 0.009 ± 0.006 μM against L100I, K103N, Y181C, Y188L and E138K HIV-1 mutant strains, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2789676-44-2
-
Molecular Weight 434.45
-
Formula C25H18N6O2
-
SMILES
NC1=NC(NC2=CC=C(C=C2)C#N)=NC(OC(C=CC(C3=CC=C(C=C3)C#N)=C4)=C4OC)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jin X, et al. Structure-Based Discovery of Novel NH2-Biphenyl-Diarylpyrimidines as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Safety: From NH2-Naphthyl-Diarylpyrimidine to NH2-Biphenyl-Diarylpyrimidine. J Med Chem. 2022 Jun 23;65(12):8478-8492. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-40 Related Classifications
HY-147807 Related Classifications
Powered by Bioz