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Cat. No.: HY-Z2289

Ibrutinib impurity 5

(Synonyms: (S)-Ibrutinib)

Customer Review

Based on 1 Customer Validation

Ibrutinib Impurity 5 ((S)-Ibrutinib) is an impurity of Ibrutinib (HY-10997).

For research use only. We do not sell to patients.

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

CAS No.: 936563-97-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Ibrutinib Impurity 5 ((S)-Ibrutinib) is an impurity of Ibrutinib (HY-10997).

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	2241 nM Compound: Ibrutinib	Antiproliferative activity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34391034]
MOLM-13	IC₅₀	3953 nM Compound: Ibrutinib	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34391034]
Ramos	IC₅₀	11451 nM Compound: Ibrutinib	Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34391034]
TMD8	IC₅₀	1.5 nM Compound: Ibrutinib	Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34391034]

CAS No. 936563-97-2
Appearance Solid
Molecular Weight 440.50
Formula C₂₅H₂₄N₆O₂
Color White to off-white
SMILES

C=CC(N1C[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O
Synonyms

(S)-Ibrutinib
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)