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Cat. No.: HY-W026339

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IMB-XMA0038

IMB-XMA0038 is a MtASADH inhibitor with an IC₅₀ value of 0.59 μg/mL. IMB-XMA0038 inhibits various agent-resistant Mycobacteria tuberculosis potently with MICs of 0.25-0.5 μg/mL. IMB-XMA0038 shows anti-tuberculosis activity.

For research use only. We do not sell to patients.

CAS No.: 921812-26-2
Formula: C₁₁H₁₀N₄O₆
Molecular Weight:294.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IMB-XMA0038 Chemical Structure

CAS No.: 921812-26-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.59 μg/mL (MtASADH)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	>218 μM Compound: 89	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 35612311]
Vero	CC₅₀	>218 μM Compound: 89	Cytotoxicity against African green monkey Vero cells by MTT assay Cytotoxicity against African green monkey Vero cells by MTT assay	[PMID: 35612311]

Chemical Information

CAS No. 921812-26-2
Molecular Weight 294.22
Formula C₁₁H₁₀N₄O₆
SMILES

[O-][N+](C1=CC=C(C(NC2=NN=C(C3OCCC3)O2)=O)O1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al. IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis. Emerg Microbes Infect. 2021 Dec;10(1):2291-2299. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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