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Cat. No.: HY-181449

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CAY10729

CAY10729 (Compound 21) is a selective PAD2 inhibitor. CAY10729 inhibits neutrophil extracellular trap formation.

For research use only. We do not sell to patients.

CAS No.: 1644666-57-8
Formula: C₁₉H₂₆ClN₇O₃
Molecular Weight:435.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAY10729 Chemical Structure

CAS No.: 1644666-57-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CAY10729 (Compound 21) is a selective PAD2 inhibitor. CAY10729 inhibits neutrophil extracellular trap formation^[1].

IC₅₀ & Target^[1]

PAD2

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	EC₅₀	985 μM Compound: 21	Cytotoxicity against human neutrophils assessed as cell viability after 4 hrs by XTT assay Cytotoxicity against human neutrophils assessed as cell viability after 4 hrs by XTT assay	[PMID: 25559347]

In Vitro

CAY10729 (1-500 μM; 4 h) exhibits extremely low cytotoxicity toward neutrophils, with an EC₅₀ of 985 μM^[1].
CAY10729 (200 mM) inhibits neutrophil extracellular trap formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human osteosarcoma (U2OS) cells
Concentration:

20 μM
Incubation Time:

72 h
Result:

Showed no reduction in U2OS cell viability relative to DMSO-treated controls.

Chemical Information

CAS No. 1644666-57-8
Molecular Weight 435.91
Formula C₁₉H₂₆ClN₇O₃
SMILES

O=C(C1=C(C=CC=C1)C(O)=O)N[C@H](C2=NN(N=N2)C(C)(C)C)CCCNC(CCl)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Subramanian V, et al. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015;58(3):1337-1344. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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