ORG 30276
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
For research use only. We do not sell to patients.
- CAS No.: 83539-08-6
- Formula: C69H91Cl2N17O14
- Molecular Weight:1453.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 83539-08-6
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Molecular Weight 1453.47
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Formula C69H91Cl2N17O14
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Synonyms
APTAA-LHRH
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Sequence
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}-Ser-Tyr-{d-Arg}-Leu-Arg-Pro-{d-Ala}
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Sequence Shortening
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}SY-{d-Arg}-LRP-{d-Ala}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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