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Cat. No.: HY-101643

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RP-60503

RP-60503 is an orally active anxiolytic cyclopyrrolone derivative with low sedative potential. RP-60503 binds to the gamma-aminobutyric acidA (GABA)/benzodiazepine receptor with a K_i value of 1.16 nM. RP-60503 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

CAS No.: 117705-18-7
Formula: C₂₂H₁₉ClN₄O₄
Molecular Weight:438.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

RP-60503 Chemical Structure

CAS No.: 117705-18-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

RP-60503 protects mice against pentylenetetrazole-induced seizures with ID₅₀ values of 5.96 mg/kg^[1].
RP-60503 (5 mg/kg, p.o.) shows anxiolytic effect in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 117705-18-7
Molecular Weight 438.86
Formula C₂₂H₁₉ClN₄O₄
SMILES

O=C(OC1N(C2=NC3=NC(Cl)=CC=C3C=C2)C(C4=C1C=CC=C4)=O)CCCNC(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Doble A, et al. RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent. J Pharmacol Exp Ther. 1993 Sep;266(3):1213-26. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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