Izicopan
Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses.
For research use only. We do not sell to patients.
- CAS No.: 2489430-53-5
- Formula: C33H31F8N3O2
- Molecular Weight:653.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
C5aR1 (CD88) is the major G protein-coupled receptor for the terminal complement anaphylatoxin C5a. Upon binding to C5a, it amplifies Ca2+ mobilization, chemotaxis, degranulation and proinflammatory cytokine release, and serves as a key oral small-molecule target for blocking complement-mediated inflammation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2489430-53-5
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Molecular Weight 653.61
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Formula C33H31F8N3O2
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SMILES
O=C(C1=C(C=CC=C1F)F)N2[C@@H](C3=CC=C(C=C3)NC4CCCC4)[C@H](C[C@H](C2)C(F)(F)F)C(NC5=CC(C(F)(F)F)=C(C=C5)C)=O
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Synonyms
INF056
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)