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製品番号: HY-189133

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ARN24092

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2746327-43-3
分子式: C₁₇H₂₅F₃N₂O₅S
分子量:426.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ARN24092 構造式

CAS 番号: 2746327-43-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
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生物活性

製品説明

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome^[1].

IC₅₀ & Target

^[1]

NKCC1

体外実験

ARN24092 (compound 40) (10-100 μM; 15 min) significantly inhibits NKCC1 in cultured hippocampal neurons, with an inhibition rate of 13.9% at 10 μM and 51.9% at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

ARN24092 (compound 40) (0.6 mg/kg; intraperitoneal injection; daily; approximately 21 days) improved cognitive impairment across four different behavioral tasks in the Ts65Dn mouse model of Down syndrome without producing any diuretic effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ts65Dn (C57BL/6JEi × C3H/HeSnJ F1 background, adult males, 2-4 months old for diuresis; 8-16 weeks old for behavioral testing)^[1]
Dosage:

0.6 mg/kg
Administration:

i.p.; daily; ~21 days
Result:

Did not induce significant diuresis in WT or Ts65Dn mice.
Fully restored short-term working memory in Ts65Dn mice in T-maze.
Completely rescued poor novel-discrimination ability in Ts65Dn mice in NOR task.
Completely restored associative memory in Ts65Dn mice in CFC test.
Rescued hyperactivity in Ts65Dn mice in open-field test.
Did not affect general health or body weight after 3 weeks of daily administration.

化学情報

CAS 番号 2746327-43-3
分子量 426.45
分子式 C₁₇H₂₅F₃N₂O₅S
SMILES

O=C(C1=C(O)C=C(NCCCCCCCC(F)(F)F)C(S(=O)(N(C)C)=O)=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Borgogno M, et al. Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome. J Med Chem. 2021 Jul 22;64(14):10203-10229.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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