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製品番号: HY-129340

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AS-183

AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.

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CAS 番号: 147317-12-2
分子式: C₁₉H₃₄O₃
分子量:310.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AS-183 構造式

CAS 番号: 147317-12-2

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Acyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	25.5 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]
HepG2	IC₅₀	18.1 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]
THP-1	IC₅₀	34.5 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]

化学情報

CAS 番号 147317-12-2
分子量 310.47
分子式 C₁₉H₃₄O₃
SMILES

O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
Structure Classification
- Others
Initial Source
- Microorganisms
Scedosporium sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993): 1196-1202. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
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AS-183

Acyltransferase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AS-183 関連分類

HY-129340 関連分類