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United States

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製品番号: HY-190158

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AZ-007

AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2488429-19-0
分子式: C₁₄H₁₂N₄S
分子量:268.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-007 構造式

CAS 番号: 2488429-19-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AZ-007 binds to the 14-3-3σ/p53^pT387 interface in X-ray crystallography (PDB 6RWH) and produces no additional electron density in 14-3-3σ/TAZ^pS89 crystals, supporting selective targeting of the p53-bound interface over the TAZ-bound interface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 2488429-19-0
分子量 268.34
分子式 C₁₄H₁₂N₄S
SMILES

N=C(N)C1=CC(C2=CC=CC=C2)=C(C3=CN=CN3)S1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Guillory X, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry. 2020 Jul 09;63(13):6694-6707.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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