BmP02
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C115H182N36O41S7
- 分子量:2949.35
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Kv1.3, Kv4.2[1]
化学情報
-
分子量 2949.35
-
分子式 C115H182N36O41S7
-
配列
Val-Gly-Cys-Glu-Glu-Cys-Pro-Met-His-Cys-Lys-Gly-Lys-Asn-Ala-Lys-Pro-Thr-Cys-Asp-Asp-Gly-Val-Cys-Asn-Cys-Asn-Val (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
-
シーケンスの短縮
VGCEECPMHCKGKNAKPTCDDGVCNCNV (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wu B, et al. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431. [Content Brief]
[2]. Wu B, et al. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel). 2016 Sep 27;8(10):280. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BmP02 関連分類
HY-P5157 関連分類
Powered by Bioz