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製品番号: HY-16108

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BMS-187745

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 157126-18-6
分子式: C₁₆H₁₉O₇PS
分子量:386.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-187745 構造式

CAS 番号: 157126-18-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle^[1].

IC₅₀ & Target

Squalene Synthase^[1]

体外実験

BMS-187745 (10-2000 μM; 48 h) does not induce significant myotoxicity (changes in protein synthesis, total protein or LDH release) in primary cultures of neonatal rat skeletal muscle cells at concentrations up to 1000 μM, with only mild irreversible cytotoxicity observed at the highest tested concentration of 2000 μM^[1].
BMS-187745 (0.1-100 μM) potently inhibits de novo cholesterol synthesis in primary cultures of neonatal rat skeletal muscle cells, with an IC₅₀ of 6.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 157126-18-6
分子量 386.35
分子式 C₁₆H₁₉O₇PS
SMILES

O(C1=CC(CCC[C@@H](P(=O)(O)O)S(=O)(=O)O)=CC=C1)C2=CC=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Flint OP, et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicology and applied pharmacology. 1997 Jul;145(1):91-8. [Content Brief]

[2]. Sun C Q, et al. A general synthesis of dioxolenone prodrug moieties[J]. Tetrahedron Letters, 2002, 43(7): 1161-1164.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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