482-70-2
482-70-2
Chemical Structure
Chimaphilin
- CAS 番号: 482-70-2
- Formula:C12H10O2
- Molecular Weight:186.21
IUPAC Name: 2,7-dimethylnaphthalene-1,4-dione
InChIKey: YZACZIYTZCJVSN-UHFFFAOYSA-N
SMILES: O=C1C(C)=CC(C2=C1C=C(C)C=C2)=O
Biological Activity: Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].
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Chimaphilin | 99.80% | Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola. | ||||||||||||||||||||
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References
- [1]. Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. [Content Brief]
- [2]. Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8. [Content Brief]
