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United States

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製品番号: HY-175005

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CF-Carvacrol

CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₀H₂₃ClO₃
分子量:346.85

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CF-Carvacrol 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PPAR アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体内実験

CF-Carvacrol (46.3-185.2 mg/kg (0.1335-0.534 mmol/kg), i.g. daily, 7 days) demonstrates a significant and dose-dependent lipid-lowering effect in hyperlipidemic Kunming (KM) mice^[1].
CF-Carvacrol (572.3 g/kg (1.65 mol/kg), i.g. daily, a month) decreases AST, ALT, and AKP levels in mouse plasma, mitigates oxidative stress and inflammation, and ameliorates liver tissue morphology in KM mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)^[1]
Dosage:

46.3, 92.6, 185.2 mg/kg
Administration:

i.g. daily for 7 days
Result:

Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).

Animal Model:

KM mice (20 g)^[1]
Dosage:

572.3 g/kg
Administration:

i.g. daily for a month
Result:

Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF).
Decreased ALT and AKP levels.
Elevated the levels of plasma SOD and GSH.
Elicited minimal oxidative stress response.
Decreased TNF-α and IL-6 levels compared to the CF group.
Showed no central venous congestion and extensive infiltration of inflammatory cells.
Upregulated the expression of Nrf2 and HO-1 proteins.

化学情報

分子量 346.85
分子式 C₂₀H₂₃ClO₃
SMILES

CC(C1=CC(OC(C(C)(OC2=CC=C(C=C2)Cl)C)=O)=C(C=C1)C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shi X, et al. Optimization of clofibrate by carvacrol results in a new hypolipidemic compound with low hepatic injury. Bioorg Med Chem Lett. 2025 May 1;120:130116./ [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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CF-Carvacrol

PPAR アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示