Corydine
Based on 1 Customer Validation
Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC50 of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC50 of 0.51 μM for MOR, and a Ki of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.93%
- CAS 番号: 476-69-7
- 分子式: C20H23NO4
- 分子量:341.40
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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HIV-1 356.7 μg/mL (IC50) |
μ Opioid Receptor/MOR 0.51 μM (EC50) |
μ Opioid Receptor/MOR 2.82 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>200 μM
Compound: 2
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Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
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[PMID: 29103873] |
| HepG2 | IC50 |
>200 μM
Compound: 2
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 29103873] |
| KB | IC50 |
>733 μM
Compound: Corydine
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Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
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[PMID: 11141105] |
| MGC-803 | IC50 |
>200 μM
Compound: 2
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Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
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[PMID: 29103873] |
Corydine (5-450 μg/mL; 1 h) inhibits the enzymatic activity of HIV-1 reverse transcriptase in vitro, with an IC50 of 356.8 μg/mL, and reduces the enzymatic activity by 40% at a concentration of 450 μg/mL[1].
Corydine (60 min) binds to and moderately activates the human μ-opioid receptor expressed on the cell membrane of CHO-hMOR, with a Ki value of 2.82 μM and an EC50 value of 0.51 μM[2].
Corydine (24 h) inhibits the proliferation of P388 and L1210 leukemia cells as well as Colon 26 colon cancer cells, with IC50 values of 23.3 μg/mL, 25.9 μg/mL, and 8.4 μg/mL, respectively[3].
Corydine (44 h) inhibits concanavalin A (Con A)-induced splenic lymphocyte proliferation in mice, with an IC50 of 15.7 μg/mL[3].
Corydine (20 h) inhibits the proliferation of mouse IL-2-dependent CTLL2 cells in vitro, with an IC50 of 10.5 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice (male, 7-8 weeks old, 30-35 g, acetic acid-induced visceral pain model)[2]
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Dosage:5 mg/kg
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Administration:s.c.; single dose
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Result:Produced a significant 51% reduction in the number of writhes compared to control mice.
Was completely abolished in antinociceptive effect by pretreatment with the mu opioid receptor antagonist naltrexone.
Caused no alterations in general behavior (sedation, motor impairment) at the tested dose.
化学情報
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CAS 番号 476-69-7
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性状 Solid
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分子量 341.40
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分子式 C20H23NO4
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Color White to off-white
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SMILES
OC1=C(OC)C=C2C3=C1C(C(OC)=C(OC)C=C4)=C4C[C@]3([H])N(CC2)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Kaserer T, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020;10(1):13804. Published 2020 Aug 14. [Content Brief]
[3]. Kondo Y, et al. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. J Pharmacobiodyn. 1990;13(7):426-431. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Corydine 関連分類
HY-N2571 関連分類
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- Corydine
- 476-69-7
- Reverse Transcriptase
- HIV
- Opioid Receptor
- HIV-1 reverse transcriptase inhibitor
- μ-opioid receptor agonist
- human immunodeficiency virus infection
- visceral pain
- leukemia
- melanoma
- bladder cancer
- colon adenocarcinoma
- CD1 mice
- P388 cells
- L1210 leukemia cells
- Colon 26 colon cancer cells
- CTLL2 cells
- Inhibitor
- inhibitor
- inhibit