CDK9-IN-41
Based on 1 Customer Validation
CDK9-IN-41 is a potent CDK9, EGFR, HER2, and COX-2 kinases inhibitor with IC50s of 192.81 nM, 254.03 nM, 238.81 nM, and 775 nM. COX-2-IN-18 exhibits remarkable antitumor activity against leukemia cancer cells, colon cancer cells, melanoma cells, ovarian cells and breast cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.84%
- CAS 番号: 1038061-96-9
- 分子式: C18H19N3O3S2
- 分子量:389.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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CDK9 192.81 nM (IC50) |
HER2 238.81 nM (IC50) |
EGFR 254.03 nM (IC50) |
COX-2 775 nM (IC50) |
CDK9-IN-41 (Compound 3) has antitumor activity presented as growth inhibition percentages (GI%) for 59 subpanel tumor cell lines. Leukemia (CCRF-CEM, 20%; HL-60(TB), 30%; MOLT-4, 20%; RPMI-8226, 20%; SR, 19%), NSC Lung (A549/ATCC, 20%; HOP-92, 14%; NCI-H322M, 19%; NCI-H23, 12%; NCI-H522, 24%), Colon (HCT-116, 21%; HCT-15, 12%), CNS (SF-539, 12%; SNB-19, 12%; U251, 12%), Melanoma (LOX IMVI, 23%; MALME-3 M, 25%; SK-MEL-5, 11%; UACC-62, 24%), Ovarian (OVCAR-8, 12%; A-498, 12%; RXF-393, 13%; UO-31, 35%), Prostate (PC-3, 13%), Breast (MDA-MB-231/ATCC, 29%; HS-578 T, 18%; T-47D, 15%; MDA-MB-468, 12%)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1038061-96-9
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性状 Solid
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分子量 389.49
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分子式 C18H19N3O3S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(CCN2C(SCC)=NC3=C(C=CC=C3)C2=O)C=C1)(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (269 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK9-IN-41 関連分類
HY-147794 関連分類
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