Ganoderic acid Mk
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 110024-14-1
- 分子式: C34H50O7
- 分子量:570.76
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Caspase アイソフォーム固有の製品をすべて表示
More
生物活性
|
Caspase-3 |
Caspase-9 |
Ganoderic acid Mk (0-100 μM, 24 h) exhibits stronger cytotoxicity to human cancer cells than human normal cell lines[1].
Ganoderic acid Mk (0-40 μM, 12-48 h) has a dose-dependent inhibitory effect on proliferation of HeLa cells[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces HeLa cells apoptosis[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces ROS burst, MMP decrease and caspase-3, -9 activities increase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa)
-
Concentration:0-100 μM
-
Incubation Time:24 h
-
Result:Exhibited stronger cytotoxicity to human cancer cells (IC50 values were ranged within 29.8-44.2 µM) than human normal cell lines (IC50 values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively).
-
Cell Line:HeLa cells
-
Concentration:0, 5, 10, 20, 40 μM
-
Incubation Time:12, 24, 48 h
-
Result:Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner.
-
Cell Line:HeLa cells
-
Concentration:0, 10, 20, 40 μM
-
Incubation Time:24 h
-
Result:Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases.
化学情報
-
CAS 番号 110024-14-1
-
分子量 570.76
-
分子式 C34H50O7
-
SMILES
O=C(/C(C)=C/CC(C(C1CC([C@@]2(C)C3=CCC4[C@](C)(CCC(C4(C)C)OC(C)=O)C3=CC[C@]12C)O)C)OC(C)=O)O
-
別名
GA-Mk
-
Structure Classification
-
Initial Source
glossy ganoderma
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ganoderic acid Mk 関連分類
HY-N11643 関連分類
Powered by Bioz