LPAR6 - lysophosphatidic acid receptor 6 Gene

Also Known as LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10161

About LPAR6

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,389,571-48,444,669 (from NCBI)

This gene has 9 transcripts (splice variants), 244 orthologues, 16 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

LPAR6 Products (11)

mRNA	Protein	Name
XM_047430022.1	XP_047285978.1	lysophosphatidic acid receptor 6 isoform X1
XM_047430024.1	XP_047285980.1	lysophosphatidic acid receptor 6 isoform X3
XM_047430023.1	XP_047285979.1	lysophosphatidic acid receptor 6 isoform X2
XM_047430020.1	XP_047285976.1	lysophosphatidic acid receptor 6 isoform X1
NM_001162498.3	NP_001155970.1	lysophosphatidic acid receptor 6
XM_047430021.1	XP_047285977.1	lysophosphatidic acid receptor 6 isoform X1
NM_001377316.2	NP_001364245.1	lysophosphatidic acid receptor 6
NM_001377317.2	NP_001364246.1	lysophosphatidic acid receptor 6
NM_005767.7	NP_005758.2	lysophosphatidic acid receptor 6
XM_047430019.1	XP_047285975.1	lysophosphatidic acid receptor 6 isoform X1
NM_001162497.3	NP_001155969.1	lysophosphatidic acid receptor 6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in plasma membrane	IDA IDA: Inferred from direct assay	18297070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR6 Protein Structure

7tm_1

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
lysophosphatidic acid receptor 6	G-protein coupled purinergic receptor P2Y5 LPA receptor 6 P2Y purinoceptor 5 RB intron encoded G-protein coupled receptor oleoyl-L-alpha-lysophosphatidic acid receptor purinergic receptor 5 purinergic receptor P2Y G protein-coupled protein 5 purinergic receptor P2Y, G-protein coupled, 5

LPAR6 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	LPAR6	P43657	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	LPAR6	P43657	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	LPAR6	P43657	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	LPAR6	P43657	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Leukocoria	Leucocoria
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Hypotrichosis 11	HYPT11 Hypotrichosis, Type 11
Unilateral Retinoblastoma
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Woolly Hair, Autosomal Dominant	Autosomal Dominant Woolly Hair ADWH Woolly Hair Autosomal Dominant
Woolly Hair, Autosomal Recessive 3	ARWH3 Woolly Hair, Autosomal Recessive 3, With Hypotrichosis Autosomal Recessive Woolly Hair 3 Woolly Hair Autosomal Recessive 3
Hypotrichosis, Congenital, With Juvenile Macular Dystrophy	HJMD Congenital Hypotrichosis With Juvenile Macular Dystrophy Hypotrichosis With Cone-Rod Dystrophy Hypotrichosis With Juvenile Macular Dystrophy Juvenile Macular Degeneration And Hypotrichosis Juvenile Macular Dystrophy And Congenital Hypotrichosis Hypotrichosis With Juvenile Macular Degeneration Hypotrichosis Congenital With Juvenile Macular Dystrophy
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Hypotrichosis 13	HYPT13 Hypotrichosis With Woolly Hair Hypotrichosis, Type 13
Hypotrichosis 4	HYPT4 Marie Unna Hereditary Hypotrichosis 1 Muhh1 Hypotrichosis, Marie Unna Type, 1 Hypotrichosis Marie Unna 1 Marie Unna Hereditary Hypotrichosis Type 1 Hypotrichosis, Hereditary, Marie Unna Type, 1 Hypotrichosis, Type 4
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Hypotrichosis
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Hypotrichosis Simplex	Hereditary Hypotrichosis Simplex Hhs
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Bilateral Retinoblastoma
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Hypotrichosis 3	HYPT3 Hypotrichosis Simplex Of The Scalp 2 Htss2 Hypotrichosis, Type 3
Hypotrichosis 7	Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis HYPT7 Hypotrichosis, Localized, Autosomal Recessive 2 Lah2 Ah Total Hypotrichosis, Mari Type Wh/Ht Hypotrichosis, Autosomal Recessive Hypotrichosis, Total, Mari Type Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis Total Mari Type Hypotrichosis Alopecia Universalis Congenita, Mari Type Mari Type Alopecia Universalis Congenita Autosomal Recessive Hypotrichosis Autosomal Recessive Localized Hypotrichosis Autosomal Recessive Woolly Hair With Or Without Hypotrichosis Htl Hypotrichoses Hypotrichosis Lah Alopecia Universalis Congenita Mari Type Hypotrichosis Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 2 Total Hypotrichosis Mari Type Woolly Hair Autosomal Recessive 2 ARWH2 Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Hypotrichosis 6	HYPT6 Lah1 Hypotrichosis, Localized, Autosomal Recessive Monilethrix-Like Hypotrichosis Hypotrichosis, Localized, Autosomal Recessive 1 Lah Htl Autosomal Recessive Localized Hypotrichosis Hypotrichosis Localized Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 1 Hypotrichosis, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07761	LPAR6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07762	Lpar6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07763	Lpar6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	LPAR6	VGNC	VGNC:74292
Rattus norvegicus	LPAR6	RGD	RGD:1595950
Bos taurus	LPAR6	VGNC	VGNC:30960
Felis catus	LPAR6	VGNC	VGNC:82329
Mus musculus	LPAR6	MGD	MGI:1914418
Canis familiaris	LPAR6	VGNC	VGNC:42747
Others	LPAR6	NCBI