BTN3A3 - butyrophilin subfamily 3 member A3 Gene

Also Known as BTF3; BTN3.3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10384

About BTN3A3

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,440,504-26,453,415 (from NCBI)

This gene has 15 transcripts (splice variants), 41 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 36.1), lymph node (RPKM 22.4) and 24 other tissues.

Summary

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

BTN3A3 Products (3)

mRNA Protein Name
NM_001242803.2 NP_001229732.1 butyrophilin subfamily 3 member A3 isoform c
NM_006994.5 NP_008925.1 butyrophilin subfamily 3 member A3 isoform a precursor
NM_197974.3 NP_932078.2 butyrophilin subfamily 3 member A3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
29339503 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
22767497 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
22767497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN3A3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 134)

PRY

PRY: SPRY-associated domain (342 - 390)

SPRY

SPRY: SPRY domain (392 - 499)

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  • 200
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  • 400
  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 3 member A3

  • butyrophilin 3

BTN3A3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
BTN3A3 O00478 BTN3A1 Homo sapiens O00481
Anti Tag CoIP
33961781
Intra
BTN3A3 O00478 BTN3A1 Homo sapiens O00481
Anti Tag CoIP
29339503
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN3A3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7685 BTN3A3 Protein, Human (HEK293, His) O00478 (Q30-W248) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01675 BTN3A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown