TMED2 - transmembrane p24 trafficking protein 2 Gene

Also Known as p24; P24A; RNP24; p24b1; p24beta1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10959

About TMED2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,584,552-123,598,582 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), colon (RPKM 110.3) and 25 other tissues.

Summary

Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED2 Products (2)

mRNA	Protein	Name
NM_001321445.2	NP_001308374.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.4	NP_006806.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10359607	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17693410	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	20427317	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	10761932	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	20361938	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	12237308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED2 Protein Structure

EMP24_GP25L

0
100
201 a.a.

Protein Preferred Names	Protein Names
transmembrane emp24 domain-containing protein 2	coated vesicle membrane protein

TMED2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TMED2	Q15363	CD59	Homo sapiens	P13987	Anti Tag CoIP	20427317
Intra	TMED2	Q15363	CD59	Homo sapiens	P13987	Anti Bait CoIP	20427317
Intra	TMED2	Q15363	F2RL1	Homo sapiens	P55085	Confocal	17693410
Intra	TMED2	Q15363	F2RL1	Homo sapiens	P55085	Pull Down	21219331
Intra	TMED2	Q15363	CASR	Homo sapiens	P41180	Anti Tag CoIP	20361938
Intra	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Tag CoIP	35271311
Intra	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	18287528
Intra	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	12237308
Intra	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Tag CoIP	33961781
Intra	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	16641999

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Epiphyseal Dysplasia, Multiple, 3	EDM3 Multiple Epiphyseal Dysplasia 3 Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy Epiphyseal Dysplasia Multiple 3 Dysplasia, Epiphyseal, Multiple, Type 3
Cardiomyopathy, Dilated, 1m	Dilated Cardiomyopathy 1m CMD1M Cardiomyopathy, Dilated 1m Cardiomyopathy, Dilated, Type 1m
Cardiomyopathy, Familial Hypertrophic, 7	Hypertrophic Cardiomyopathy 7 CMH7 Cardiomyopathy, Familial Hypertrophic 7 Cardiomyopathy, Hypertrophic, 7 Cardiomyopathy, Hypertrophic, Familial, Type 7
B-Lymphoblastic Leukemia/Lymphoma Mll Rearranged	B-Lymphoblastic Leukemia/Lymphoma Kmt2a Rearranged B Lymphoblastic Leukemia/Lymphoma With T Mll Rearranged B-All Kmt2a Rearranged B-Lymphoblastic Leukemia/Lymphoma With T Kmt2a Rearranged
Cardiomyopathy, Dilated, 1p	Dilated Cardiomyopathy 1p CMD1P Cardiomyopathy, Dilated 1p Cardiomyopathy, Dilated, Type 1p
Epiphyseal Dysplasia, Multiple, 1	EDM1 Multiple Epiphyseal Dysplasia 1 Multiple Epiphyseal Dysplasia Type 1 Med1 Multiple Epiphyseal Dysplasia Comp-Related Polyepiphyseal Dysplasia Type 1 Multiple Epiphyseal Dysplasia, Comp-Related Epiphyseal Dysplasia Multiple 1 Epiphyseal Dysplasia, Multiple 1 Dysplasia, Epiphyseal, Multiple, Type 1
Epiphyseal Dysplasia, Multiple, 2	EDM2 Multiple Epiphyseal Dysplasia 2 Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Ovarian Mucinous Adenocarcinoma	Mucinous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14636	TMED2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21788	Tmed2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28304	Tmed2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	TMED2	VGNC	VGNC:80502
Canis familiaris	TMED2	VGNC	VGNC:57417
Rattus norvegicus	TMED2	RGD	RGD:69243
Mus musculus	TMED2	MGD	MGI:1929269