FKBP3 - FKBP prolyl isomerase 3 Gene

Also Known as FKBP-3; FKBP25; PPIase; FKBP-25

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2287

About FKBP3

Cytogenetic location: 14q21.2 Genomic coordinates (GRCh38): 14:45,115,599-45,134,481 (from NCBI)

This gene has 4 transcripts (splice variants), 235 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, Casein Kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

FKBP3 Products (1)

mRNA Protein Name
NM_002013.4 NP_002004.1 peptidyl-prolyl cis-trans isomerase FKBP3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
19166840 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP3 Protein Structure

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (122 - 221)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP3

  • 25 kDa FK506-binding protein

FKBP3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
FKBP3 Q00688 MDM2 Homo sapiens Q00987
Y2H
19166840
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FKBP3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70403 FKBP3 Protein, Human (His) Q00688 (M1-D224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04963 FKBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20406 Fkbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26915 Fkbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta FKBP3 VGNC VGNC:84339
Rattus norvegicus FKBP3 RGD RGD:1304992
Felis catus FKBP3 VGNC VGNC:80972
Bos taurus FKBP3 VGNC VGNC:29022
Canis familiaris FKBP3 VGNC VGNC:50526
Mus musculus FKBP3 MGD MGI:1353460
Others FKBP3 NCBI