LHB - luteinizing hormone subunit beta Gene
Also Known as CGB4; HH23; LSH-B; LSH-beta
生物種: Homo sapiens
About LHB
This gene has 2 transcripts (splice variants), 27 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in pancreas (RPKM 1.7), testis (RPKM 1.1) and 7 other tissues.
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize Steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
LHB Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000894.3 | NP_000885.1 | lutropin subunit beta precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
LHB Protein Structure
Cys_knot: Cystine-knot domain (27 - 130)
- 0
- 100
- 141 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
lutropin subunit beta |
|
LHB Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
LHB | P01229 | NTM | Homo sapiens | Q9P121-3 | 32296183 | |
|
Intra
|
LHB | P01229 | FHL3 | Homo sapiens | Q13643 | 32296183 | |
|
Intra
|
LHB | P01229 | FHL3 | Homo sapiens | Q13643 | 32296183 | |
|
Intra
|
LHB | P01229 | FHL3 | Homo sapiens | Q13643 | 32296183 | |
|
Intra
|
LHB | P01229 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
LHB | P01229 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
LHB | P01229 | SGTB | Homo sapiens | Q96EQ0 | 32296183 |
LHB 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P81350 | Luteinizing Hormone beta Antibody (YA1095) | IHC-P | Human |
| HY-P81350A | Luteinizing Hormone beta Antibody (YA1095)(PBS only) | IHC-P | Human |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Hypogonadotropic Hypogonadism 23 With Or Without Anosmia |
|
|
| Hypogonadism |
|
|
| Amenorrhea |
|
|
| Infertility |
|
|
| Hypogonadism, Male |
|
|
| Hypogonadotropic Hypogonadism |
|
|
| Drug Psychosis |
|
|
| Drug-Induced Mental Disorder |
|
|
| Substance-Induced Psychosis |
|
|
| Pseudohermaphroditism |
|
|
| Male Infertility |
|
|
| Leydig Cell Hypoplasia Type Ii |
|
|
| Kallmann Syndrome |
|
|
| Hemophagocytic Lymphohistiocytosis, Familial, 3 |
|
|
| Major Depressive Disorder |
|
|
| Mental Depression |
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | LHB | MGD | MGI:96782 |
| Rattus norvegicus | LHB | RGD | RGD:3006 |
| Others | LHB | NCBI |