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PCYOX1 - prenylcysteine oxidase 1 Gene

Also Known as PCL1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51449

About PCYOX1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,257,915-70,281,185 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues.

Summary

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

PCYOX1 Products (1)

mRNA	Protein	Name
NM_016297.4	NP_057381.3	prenylcysteine oxidase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables FAD binding	IDA IDA: Inferred from direct assay	11078725	GOA
enables prenylcysteine oxidase activity	IDA IDA: Inferred from direct assay	10585463	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in prenylated protein catabolic process	IDA IDA: Inferred from direct assay	10585463	GOA
involved in prenylcysteine catabolic process	IDA IDA: Inferred from direct assay	11078725	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in lysosome	IDA IDA: Inferred from direct assay	10585463	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	17154273	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCYOX1 Protein Structure

NAD_binding_8

Prenylcys_lyase

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
prenylcysteine oxidase 1	prenylcysteine lyase

関連疾患

Diseases	Alias
Coenzyme Q10 Deficiency, Primary, 9	COQ10D9 Primary Coenzyme Q10 Deficiency 9
Developmental And Epileptic Encephalopathy 33	DEE33 Epileptic Encephalopathy, Early Infantile, 33 Eiee33 Developmental And Epileptic Encephalopathy, 33 Early Infantile Epileptic Encephalopathy 33 Encephalopathy, Epileptic, Early Infantile, Type 33
Immunodeficiency 50	Combined Immunodeficiency Due To Moesin Deficiency IMD50 Immunodeficiency 50, X-Linked Recessive Cid Due To Moesin Deficiency Msn-Related Combined Immunodeficiency X-Linked Moesin-Associated Immunodeficiency Immunodeficiency 50 X Linked Recessive
Charcot-Marie-Tooth Disease, Axonal, Type 2cc	Charcot-Marie-Tooth Disease Axonal Type 2cc CMT2CC Charcot-Marie-Tooth Neuropathy, Type 2cc Charcot-Marie-Tooth Neuropathy Type 2cc Charcot-Marie-Tooth Disease 2cc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS10179	PCYOX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	PCYOX1	VGNC	VGNC:44327
Rattus norvegicus	PCYOX1	RGD	RGD:628652
Bos taurus	PCYOX1	VGNC	VGNC:32650
Macaca mulatta	PCYOX1	VGNC	VGNC:75658
Mus musculus	PCYOX1	MGD	MGI:1914131
Felis catus	PCYOX1	VGNC	VGNC:64074
Others	PCYOX1	NCBI