CDKN2AIP - CDKN2A interacting protein Gene

Also Known as CARF

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 55602

About CDKN2AIP

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,444,636-183,449,064 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.6), bone marrow (RPKM 11.5) and 25 other tissues.

Summary

The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

CDKN2AIP Products (2)

mRNA Protein Name
NM_001317343.2 NP_001304272.1 CDKN2A-interacting protein isoform 2
NM_017632.4 NP_060102.1 CDKN2A-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables p53 binding IDA
IDA: Inferred from direct assay
15109303 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12581788 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA damage response IDA
IDA: Inferred from direct assay
24825908 GOA
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
12154087 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
24825908 GOA
involved in positive regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
15109303 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
12154087 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in granular component IDA
IDA: Inferred from direct assay
12154087 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
12154087 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
12154087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKN2AIP Protein Structure

XTBD

XTBD: XRN-Two Binding Domain, XTBD (19 - 125)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

CDKN2A-interacting protein

  • collaborates/cooperates with ARF (alternate reading frame) protein

CDKN2AIP Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CDKN2AIP Q9NXV6 XRN2 Homo sapiens Q9H0D6
Anti Tag CoIP
26496610
Intra
CDKN2AIP Q9NXV6 XRN2 Homo sapiens Q9H0D6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Spleen Angiosarcoma

  • Angiosarcoma Of Spleen

  • Splenic Hemangiosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-177554 KB05yne 99.97% Unkown
HY-185414 KB05-Biotin / Unkown
HY-RS02415 CDKN2AIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus CDKN2AIP VGNC VGNC:107317
Canis familiaris CDKN2AIP VGNC VGNC:39070
Mus musculus CDKN2AIP MGD MGI:1918175
Macaca mulatta CDKN2AIP VGNC VGNC:100210
Rattus norvegicus CDKN2AIP RGD RGD:1305302
Bos taurus CDKN2AIP VGNC VGNC:106682
Others CDKN2AIP NCBI