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AKIP1 - A-kinase interacting protein 1 Gene

Also Known as BCA3; C11orf17

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 56672

About AKIP1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,911,189-8,920,079 (from NCBI)

This gene has 11 transcripts (splice variants) and 170 orthologues. Ubiquitous expression in thyroid (RPKM 4.3), adrenal (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

AKIP1 Products (4)

mRNA	Protein	Name
NM_001206646.2	NP_001193575.1	A-kinase-interacting protein 1 isoform b
NM_001206647.2	NP_001193576.1	A-kinase-interacting protein 1 isoform c
NM_001206648.2	NP_001193577.1	A-kinase-interacting protein 1 isoform d
NM_020642.4	NP_065693.2	A-kinase-interacting protein 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15630084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
A-kinase-interacting protein 1	A kinase (PRKA) interacting protein 1

AKIP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	Y2H	15630084
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	Pull Down	15630084
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	CoIP	15630084

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS00526	AKIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21477	Akip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27995	Akip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	AKIP1	RGD	RGD:1306959
Macaca mulatta	AKIP1	VGNC	VGNC:69600
Canis familiaris	AKIP1	VGNC	VGNC:37764
Bos taurus	AKIP1	VGNC	VGNC:25792
Felis catus	AKIP1	VGNC	VGNC:59720
Mus musculus	AKIP1	MGD	MGI:3041226
Others	AKIP1	NCBI