AKIP1 - A-kinase interacting protein 1 Gene

Also Known as BCA3; C11orf17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56672

About AKIP1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,911,189-8,920,079 (from NCBI)

This gene has 11 transcripts (splice variants) and 170 orthologues. Ubiquitous expression in thyroid (RPKM 4.3), adrenal (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

AKIP1 Products (4)

mRNA Protein Name
NM_001206646.2 NP_001193575.1 A-kinase-interacting protein 1 isoform b
NM_001206647.2 NP_001193576.1 A-kinase-interacting protein 1 isoform c
NM_001206648.2 NP_001193577.1 A-kinase-interacting protein 1 isoform d
NM_020642.4 NP_065693.2 A-kinase-interacting protein 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15630084 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase-interacting protein 1

  • A kinase (PRKA) interacting protein 1

AKIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKIP1 Q9NQ31 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
AKIP1 Q9NQ31 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
AKIP1 Q9NQ31 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
AKIP1 Q9NQ31 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
AKIP1 Q9NQ31 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
AKIP1 Q9NQ31 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
AKIP1 Q9NQ31 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
AKIP1 Q9NQ31 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
AKIP1 Q9NQ31 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
AKIP1 Q9NQ31 PRKACA Homo sapiens P17612
Y2H
15630084
Intra
AKIP1 Q9NQ31 PRKACA Homo sapiens P17612
Pull Down
15630084
Intra
AKIP1 Q9NQ31 PRKACA Homo sapiens P17612
CoIP
15630084
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00526 AKIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21477 Akip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27995 Akip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKIP1 RGD RGD:1306959
Macaca mulatta AKIP1 VGNC VGNC:69600
Canis familiaris AKIP1 VGNC VGNC:37764
Bos taurus AKIP1 VGNC VGNC:25792
Felis catus AKIP1 VGNC VGNC:59720
Mus musculus AKIP1 MGD MGI:3041226
Others AKIP1 NCBI