RPL10 - ribosomal protein L10 Gene

Also Known as QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6134

About RPL10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,398,065-154,402,339 (from NCBI)

This gene has 16 transcripts (splice variants), 103 orthologues, 1 paralogue and is associated with 52 phenotypes. Ubiquitous expression in ovary (RPKM 795.4), lymph node (RPKM 396.3) and 25 other tissues.

Summary

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though Others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RPL10 Products (6)

mRNA	Protein	Name
NM_001256577.2	NP_001243506.2	60S ribosomal protein L10 isoform b
NM_001256580.2	NP_001243509.2	60S ribosomal protein L10 isoform c
NM_001303624.2	NP_001290553.1	60S ribosomal protein L10 isoform a
NM_001303625.1	NP_001290554.1	60S ribosomal protein L10 isoform a
NM_001303626.1	NP_001290555.1	60S ribosomal protein L10 isoform d
NM_006013.5	NP_006004.3	60S ribosomal protein L10 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10508860	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	9443083	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	26290468	GOA
enables translation regulator activity	IMP IMP: Inferred from mutant phenotype	26290468	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in embryonic brain development	IMP IMP: Inferred from mutant phenotype	25316788	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10508860	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10508860	GOA
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	26290468	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	9443083	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10508860	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10508860	GOA
colocalizes with smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	10508860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL10 Protein Structure

Ribosomal_L16

0
100
200
214 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L10	Wilms tumor-related protein

RPL10 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RPL10	P27635	SRC	Homo sapiens	P12931	Anti Bait CoIP	16741966
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic, 35	MRXS35 Mental Retardation, X-Linked, Syndromic, 35 Intellectual Developmental Disorder, X-Linked Syndromic 35 Syndromic X-Linked Mental Retardation 35 X-Linked Intellectual Disability-Cerebellar Hypoplasia-Spondylo-Epiphyseal Dysplasia Syndrome X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 35 Mental Retardation, X-Linked, Syndromic, Type 35
Autism X-Linked 5	Autism, Susceptibility To, X-Linked 5 AUTSX5 Autism, X-Linked 5 Autism, Susceptibility To, X-Linked, Type 5
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Tinea Nigra	Microsporosis Nigra Infection By Cladosporium Werneckii Keratomycosis Nigricans Tinea Palmaris Nigra Keratomycosis Nigricans Palmaris
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Oculoglandular Tularemia
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Olecranon Bursitis	Bursitis Of Elbow Bursitis Of Elbow Region Capped Elbow Elbow Bursitis Miner'S Elbow Miners' Elbow Shoe Boil
Tinea Favosa	Favus
Tinea Barbae	Dermatophytosis Of Beard
Tinea Imbricata	Kerion Celsi Trichophyton Infection Tinea Imbricata, Susceptibility To Susceptibility To Tinea Imbricata Tinea Capitis Profunda Trichophytia Profunda Barbae Trichophytia Profunda Capitis Tinea Capitis
Renpenning Syndrome 1	Renpenning Syndrome Golabi-Ito-Hall Syndrome Mrxs3 Mrxs8 X-Linked Intellectual Disability Due To Pqbp1 Mutations RENS1 Sutherland-Haan X-Linked Mental Retardation Syndrome Shs Mrx55 X-Linked Intellectual Disability, Renpenning Type Sutherland-Haan Syndrome Mental Retardation, X-Linked, Renpenning Type Mental Retardation, X-Linked, With Spastic Diplegia Mental Retardation, X-Linked, Syndromic 3 Mental Retardation, X-Linked, Syndromic 8 Mental Retardation, X-Linked 55 Syndromic X-Linked Mental Retardation 8 X-Linked Mental Retardation Renpenning Type X-Linked Mental Retardation With Spastic Diplegia Sutherland-Haan X-Linked Intellectual Disability Syndrome X-Linked Intellectual Disability With Spastic Diplegia Hamel Cerebropalatocardiac Syndrome Porteous Syndrome X-Linked Intellectual Deficit Due To Pqbp1 Mutations X-Linked Intellectual Deficit, Renpenning Type X-Linked Intellectual Disability, Sutherland-Haan Type Hamel Cerebro-Palato-Cardiac Syndrome Renpenning Syndrome, Type 1
Tinea Manuum	Tinea Manus Dermatophytosis Of Hand
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12160	RPL10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12161	RPL10A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12167	RPL15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20098	Rpl10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26601	Rpl10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	RPL10	RGD	RGD:621178
Mus musculus	RPL10	MGD	MGI:105943
Others	RPL10	NCBI