Fam20c - FAM20C, golgi associated secretory pathway kinase Gene

Also Known as DMP4; DMP-4; GEF-CK; mKIAA4081

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 80752

Summary

Enables calcium ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and osteoclast maturation. Located in Golgi apparatus and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; genitourinary system; and musculoskeletal system. Used to study rickets. Human ortholog(s) of this gene implicated in amelogenesis imperfecta. Orthologous to human FAM20C (FAM20C golgi associated secretory pathway kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fam20c Products (2)

mRNA Protein Name
NM_001359593.1 NP_001346522.1 extracellular serine/threonine protein kinase FAM20C isoform 2
NM_030565.6 NP_085042.2 extracellular serine/threonine protein kinase FAM20C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables calcium ion binding IDA
IDA: Inferred from direct assay
17369251 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22900076 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within dentinogenesis IMP
IMP: Inferred from mutant phenotype
22732358 MGI
acts upstream of or within enamel mineralization IMP
IMP: Inferred from mutant phenotype
22732358 MGI
acts upstream of or within odontoblast differentiation IDA
IDA: Inferred from direct assay
17369251 MGI
acts upstream of or within osteoclast maturation IMP
IMP: Inferred from mutant phenotype
22615579 MGI
acts upstream of or within positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
17369251 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
22615579 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
22900076 MGI
acts upstream of or within regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22615579 MGI
acts upstream of or within regulation of phosphorus metabolic process IMP
IMP: Inferred from mutant phenotype
22615579 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
22615579 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22900076 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21549343 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17369251 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

extracellular serine/threonine protein kinase FAM20C

  • dentin matrix protein 4

  • family with sequence similarity 20, member C

  • golgi-enriched fraction casein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04706 FAM20C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19506 Fam20c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26000 Fam20c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Fam20c NCBI NCBI:56975